Based on in vitro studies, eribulin exerts its effect via a tubulin-based antimitotic
mechanism ultimately leading to apoptotic cell death after prolonged and irreversible mitotic blockage.
7: Delivery of coronary stents coated with cobalt-chromium antimitotic
substance derived from sirolimus;- Order partial No.
Benzo[c)cinnoline and its derivatives are important heterocyclic compounds with antirheumatoid, as well as antimitotic
Synthesis of a new 4-aza2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic
These results provide the first evidence that NovoTTF Therapy is an effective antimitotic
treatment in preclinical pancreatic cancer models and has a long term negative effect on pancreatic cancer cell survival," said Dr.
argentea, showed potent inhibition of tubulin polymerization, suggesting antimitotic
activity of these compounds [9.
The methanol extract of Achyranthesaspera Linn have antimitotic
effect to inhibit the cleavage cells (Wurlina, 2002) and inhibit spermatogenesis (Meles, 2004).
In a study by neky and shreni,  on occurrence of malformation in the process of developing cerebellar tissue, has been expressed that the intervention of antimitotic
activity drugs or X-ray in the neonatal rats will make the first damages in the pia mater of meninge .
2010a), focusing on antimitotic
effects, inhibition of protein synthesis, oxidative stress, impaired viability, and neurodifferentiation into ACh and DA phenotypes.
Mitotic drug target and the development of novel antimitotic
ENMD-1198, a novel antimitotic
agent, and ENMD-2076, a selective kinase inhibitor, are in Phase 1 studies in advanced cancers.
They act as antimitotic
agents in the epidermis by influencing gene transcription resulting in inhibition of the immunological, inflammatory and proliferative processes of the disease [14-16].