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antimycin |
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an`ti`my´cin (ăn`tĭ`mī´sĭn)
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Researchers affiliated with the National Cancer Institute and other groups have extracted compounds from marine sponges and corals that inhibit the growth of tumor cells, and a group from the Scripps Institution of Oceanography has isolated marine bacteria closely related to the terrestrial organisms from which antimycin antibiotics were originally derived. In malignant cells, the results demonstrated that rhIGFBP-3 enhanced apoptosis induced by ceramide, antimycin A and the UV-mimetic 4 NQO between 50-200%. It is generally accepted that the mitochondrion is the major source of intracellular ROS, which is enhanced by electron transport inhibitors such as ischemiareperfusion, rotenone, antimycin A, and diphenyleneiodonium (46-48). |
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