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antimycin

   Also found in: Medical, Wikipedia 0.01 sec.
an`ti`my´cin    (ăn`tĭ`mī´sĭn)
n.1.one of several antibiotic substances produced by several species of Streptomyces, active against various fungi. They are used only experimentally, not in medicine. The two best-known antimycins are antimycin A1 (C28H40N2O9) and antimycin A3 (C26H36N2O9). They are notable for their mechanism of action, interference with the proton pumping mechanism of fungi.
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Noun1.antimycin - a crystalline antibiotic active against various fungi
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"

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Researchers affiliated with the National Cancer Institute and other groups have extracted compounds from marine sponges and corals that inhibit the growth of tumor cells, and a group from the Scripps Institution of Oceanography has isolated marine bacteria closely related to the terrestrial organisms from which antimycin antibiotics were originally derived.
In malignant cells, the results demonstrated that rhIGFBP-3 enhanced apoptosis induced by ceramide, antimycin A and the UV-mimetic 4 NQO between 50-200%.
It is generally accepted that the mitochondrion is the major source of intracellular ROS, which is enhanced by electron transport inhibitors such as ischemiareperfusion, rotenone, antimycin A, and diphenyleneiodonium (46-48).
 
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