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Defective development resulting in the absence of all or part of an organ or tissue.


(Pathology) pathol congenital absence or abnormal development of an organ or part
[C19: New Latin, from a-1 + -plasia, from Greek plassein to form]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.aplasia - failure of some tissue or organ to develop
dysplasia - abnormal development (of organs or cells) or an abnormal structure resulting from such growth


n. aplasia, falta de desarrollo normal en un órgano.
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A clinical diagnosis of aplasia cutis congenita was made.
Aplasia cutis congenital (ACC) is a rare congenital anomaly characterized by partial or complete absence of the skin1.
INTRODUCTION: Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by a localized absence of skin and dermal appendages.
Faun tail with aplasia cutis congenita and diastematomyelia.
En la literatura se reportan tres variedades de atresia pilorica asociada a otras malformaciones: 1) Atresia pilorica sin otras anormalidades, 2) atresia pilorica en asociacion con otras atresias del tracto intestinal (atresia esofagica, duodenal, yeyuno-ileal y rectoanal) y 3) atresia pilorica que ocurre en asociacion con otras malformaciones geneticas evidentes como epidermolisis ampollosa y aplasia cutis.
1 It usually occurs as an isolated anomaly but it may arise in association with other congenital abnormalities mostly with epidermolysis bullosa/congenita aplasia cutis.
Additionally, the clinical overlap with other well-characterized malformations like Poland syndrome, cutis marmorata telangiectatica congenita, and aplasia cutis congenita, makes its diagnosis challenging and may compromise accurate genetic counseling and risk estimation.
Aplasia cutis congenita (ACC) comprises a heterogeneous group of disorders whose main feature is the focal absence of skin.
Propylthiouracil (PTU) has been the preferred therapy for Graves' disease during pregnancy, especially during first-trimester organogenesis, because methimazole (MMI) and carbimazole have been associated with aplasia cutis and rare embryopathy including choanal atresia, esophageal atresia, tracheoesophageal fistula, and athelia.
Levy also discussed the clinical signs of another skin defect that can affect newborns: aplasia cutis congenita.
We, herein, describe a case of 1-month-old girl with aplasia cutis, cutis marmorata telangiectatica and terminal transverse limb reduction defects with a positive HCV serology.
Aplasia cutis congenita is the absence of the skin at birth that presents with an erosion or deep ulceration to a scar or a defect that is covered with an epidermal membrane.