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Defective development resulting in the absence of all or part of an organ or tissue.


(Pathology) pathol congenital absence or abnormal development of an organ or part
[C19: New Latin, from a-1 + -plasia, from Greek plassein to form]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.aplasia - failure of some tissue or organ to develop
dysplasia - abnormal development (of organs or cells) or an abnormal structure resulting from such growth


n. aplasia, falta de desarrollo normal en un órgano.
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Carbimazole crosses the placenta, and can cause fetal hypothyroidism and goitre, and rarely a fetal abnormality called aplasia cutis, in which there are patches of absent skin on the scalp.
Propylthiouracil (PTU) has been the preferred therapy for Graves' disease during pregnancy, especially during first-trimester organogenesis, because methimazole (MMI) and carbimazole have been associated with aplasia cutis and rare embryopathy including choanal atresia, esophageal atresia, tracheoesophageal fistula, and athelia.
a burn reconstructive surgeon at University Hospital and Medical Center at Stony Brook, presented a case study of a newborn child who was treated for Aplasia Cutis Congenita of the trunk, a rare congenital condition characterized by the absence of all layers of skin.