The designation relates to the use of Promacta in combination with standard immunosuppressive therapy for the treatment of patients with severe aplastic anaemia
(SAA) as a first-line therapy.
Acquired aplastic anaemia
has been linked to many drugs, chemicals and viruses.
I have a letter from the Health and Safety Executive dated 23 Dec, 1987 admitting that exposures to benzene related derivatives like trinitrotoluene (TNT) are well known to cause aplastic anaemia
, destruction of the bone marrow and a precursor condition to leukaemia and other cancers.
Histopathological analysis of bone marrow trephine biopsies revealed megaloblastic anaemia as the most common cause of pancytopenia (30%), followed by aplastic anaemia
(25%) and hypersplenism (15%).
They told us he was suffering from severe aplastic anaemia
," said Sarah, "a rare disorder where the bone marrow fails to make enough blood cells.
Acute lymphoblastic leukaemia was the commonest cause of haematological thrombocytopenia followed by idiopathic thrombocytopenic purpura and aplastic anaemia
was found to be the commonest cause of pancytopenia, 44 cases [43.
Angelo, from Ely in Cardiff, was diagnosed with severe aplastic anaemia
in 2006 at the age of 19, a blood disorder in which the body's bone marrow doesn't make enough new blood cells.
Angelo Farrugia, 28, from Cardiff, who has severe aplastic anaemia
, needs a bone marrow transplant after donations from his sister failed Angelo Farrugia, 28, from Cardiff, who has severe aplastic anaemia
, needs a bone marrow transplant after donations from his sister
is a disease in which the bone marrow, and the blood stem cells that reside there, are damaged.
Scheinberg P, Nunez 0, Wu C, Young NS: Treatment of severe aplastic anaemia
with combined immunosuppression: anti-thymocyte globulin, cyclosporin and mycophenolate mofetil.
Successful treatment of cutaneous and subcutaneous zygomycosis in an immunosuppressed patient with aplastic anaemia