1) Between 30-67% of patients with sickle cell disease (SCD) get infected causing transient red cell aplasia (TRCA), otherwise called aplastic crisis
2) The clinical syndrome associated with HPV B19 strongly depends on the host; for instance those suffering from hemolytic disorders, including sickle cell disease, hereditary spherocytosis (HS), autoimmune hemolysis, thalassemias, and paroxysmal nocturnal hemoglobinuria (PNH) are susceptible to aplastic crisis
Among patients with sickle cell disease and acute anemia, fewer than expected had acute chest syndrome, aplastic crisis
, or splenic sequestration, although these still accounted for the majority.
The literature of PV-B19 infection with a growing number of publications has reported its association with erythema infectiosum in children, transient aplastic crisis
in persons with high red cell turnover, chronic pure red cell (PRC) aplasia in primary or secondary immunocompromised patients, hydrops fetalis with infection during pregnancy, and arthropathy, mostly in females.
High RBC turnover and heightened erythroid marrow activity in HS make children vulnerable to develop aplastic crisis
due to parvovirus and various other infections.
An aplastic crisis
can occur when the bone marrow and cell production fail.
hydrops fetalis), transient aplastic crisis
, and disease in immunocompromised patients (2).
Of significance was an outbreak of transient aplastic crisis
among children with sickle cell disease associated with this outbreak of fifth disease (Adams & Ware, 1996).