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apoptosis

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
ap·op·to·sis  (pp-tss, p-t-)
n.
Disintegration of cells into membrane-bound particles that are then eliminated by phagocytosis or by shedding.

apoptosis  (pp-tss, p-t-)
A natural process of self-destruction in certain cells, such as epithelial cells and erythrocytes, that are genetically programmed to have a limited life span or are damaged. Apoptosis can be induced either by a stimulus, such as irradiation or toxic drugs, or by removal of a repressor agent. The cells disintegrate into membrane-bound particles that are then eliminated by phagocytosis. Also called programmed cell death.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.apoptosis - a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
cell death, necrobiosis - (physiology) the normal degeneration and death of living cells (as in various epithelial cells)

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Lymphocytes, in particular, undergo massive and apparently unregulated apoptosis in human patients and laboratory animals with sepsis, potentially playing a major role in the severe immunosuppression that characterizes the terminal phase of fatal illness.
Studies have shown that inhibition or depletion of RLIP76, a glutathione-conjugate transport protein that helps cells defend themselves against toxicants, causes apoptosis in a number of cancer cell types.
By reawakening the apoptosis that seems to fail in many tumor cells, J.
 
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