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apoptosis |
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apoptosis [ˌæpəpˈtəʊsɪs] n (Life Sciences & Allied Applications / Biology) Biology the programmed death of some of an organism's cells as part of its natural growth and development Also called programmed cell death [from Greek: a falling away, from apo- + ptōsis a falling]
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| Lymphocytes, in particular, undergo massive and apparently unregulated apoptosis in human patients and laboratory animals with sepsis, potentially playing a major role in the severe immunosuppression that characterizes the terminal phase of fatal illness. Studies have shown that inhibition or depletion of RLIP76, a glutathione-conjugate transport protein that helps cells defend themselves against toxicants, causes apoptosis in a number of cancer cell types. By reawakening the apoptosis that seems to fail in many tumor cells, J. |
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