aprotinin


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Related to aprotinin: Leupeptin

a·pro·ti·nin

 (ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

[a- + prot(e)in(ase) + -in.]
References in periodicals archive ?
Seventy-five percent of the potential cost saving lay in the last item, administering aprotinin based upon clinical standards.
During the course of trial, evidence was presented that the administration of drugs Amicar or Aprotinin before surgery diminishes the risk of excessive bleeding, whereas ingestion of aspirin enhances such risk.
An experimental study of the effect of aprotinin on intestinal adhesion formation.
BNP Detection: Blood samples were collected with chilled tubes containing ethylenediaminetetraacetic acid and aprotinin 1 d before and 3 d after the operation through the peripheral vein.
4]; 1 mM NaF; 1 mM PMSF; and 10 [micro]g/mL each of aprotinin and leupeptin) and stored at -20[degrees]C.
The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis.
The second sample was collected in a tube containing, in addition to EDTA-2K, aprotinin, as a protease inhibitor (50 |xl of aprotinin solution/ml whole blood).
Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents.
This has perhaps been best voiced in a study published in the New England Journal of Medicine several years ago about the use of aprotinin in cardiac surgery.