The International Rice Genome Sequencing Project, a 10-nation consortium, is also sequencing the japonica genome using bacterial artificial chromosome
libraries, a more time-consuming but also more accurate approach.
In this instance, an artificial chromosome
that has already been modified to express a product gene can be isolated from its host cell and readily transferred to any number of other cell lines that may offer an advantage with respect to growth, expression or quality of product.
In a parallel development, Crescendo has also demonstrated the potential of its first generation yeast artificial chromosome
(YAC) with the successful expression of human antibodies.
This guide for researchers describes laboratory protocols for working with large insert yeast artificial chromosome
(YAC) DNA clones.
Chromos is achieving this objective with its Artificial Chromosome
Expression (ACE) System and Rapid Expansion Method Technologies.
Already, a Vancouver company, Chromos Molecular Systems, makes a mammalian artificial chromosome
that allows biotechnologists to plug in new genes just as new computer chips can be plugged into a motherboard.
Following a similarly adventuresome strategy, geneticists have now thrown several forms of DNA into human cells and created a long-desired prize: the first human artificial chromosome
As the creator of bacterial artificial chromosome
An artificial chromosome
will again give you unprecedented power to alter cells.
Assembly of De Novo Bacterial Artificial Chromosome
-based Human Artificial Chromosomes
Chromos' ACE System is a versatile and potent biological engineering system based on proprietary artificial chromosome
technology that facilitates the rapid engineering of stable high expressing production cell lines for the clinical and commercial manufacture of biopharmaceuticals.
These microarrays provide more rapid and precise results than karyotyping, and offer as much as 50 times higher resolution than other, more commonly used microarrays, such as bacterial artificial chromosome
arrays," said Dr.