asparaginase


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as·par·a·gin·ase

 (ə-spăr′ə-jə-nās′, -nāz′)
n.
An enzyme isolated from bacteria that catalyzes the hydrolysis of asparagine and is used in the chemotherapeutic treatment of leukemia.

asparaginase

(əˈspærədʒɪˌneɪz; əˈspærədʒɪˌneɪs)
n
(Pharmacology) an enzyme used in treating leukaemia
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.asparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemiaasparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
References in periodicals archive ?
The pre-treatments included food acids, salts and the enzyme asparaginase.
For example, the FDA says that companies can lower acrylamide by adding asparaginase (an enzyme that breaks down asparagine), calcium, or other safe additives, or by processing at lower temperatures.
The most frequent potentially interactive combination was asparaginase x Prednisolone (more severe), followed by Fluconazole x sulfamethoxazole/trimethoprim (more severe) and Fluconazole x Omeprazole (moderate severity).
1 Bla P62593 2 DsbA P0AEG4 3 Endo-1, Q59256 4-P-xylanase 4 gIII P03661 5 LamB P02943 6 L- P00805 Asparaginase II 7 LivK P04816 8 LPP P69776 9 LTB P13811 10 MalE P0AEX9 11 MglB P0AEE5 12 npr P06832 13 OmpA P0A910 14 OmpC P06996 15 OmpF P02931 16 OmpT P09169 17 Pac P06875 18 PelB Q6CZT3 19 PhoA P00634 20 PhoE P02932 21 sfmC P77249 22 ST-IA/ST-P P01559 23 STII P22542 24 TolB P0A855 25 TorA P33225 26 TorT P38683 Source Amino acid sequence 1 Escherichia coli MSIQHFRVALIPFFAAF CLPVFA 2 Escherichia coli K-12 MKKIWLALAGLVLAFSASA 3 Bacillus sp.
The L-asparaginase in current trademarks, like Paronal[R] Or Asparaginase Medac[R] which include the native Form of the enzyme produced by Escherichia coli, is From bacterial origin.
Furthermore, therapeutic enzymes such as asparaginase have been obtained from Escherichia spp.
Four agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia," The New England Journal of Medicine, vol.
Their abilities to produce asparaginase at different pH, temperature, incubation temperature, utilization of different carbon and nitrogen sources as well as their specific conditions for optimal activity were also investigated.
Three previous fairs allowed to collect more than 400 thousand som ($6,879) and purchase such drugs as flucanir, asparaginase, glucose, sodium chloride," said the arrangers.
Hematologists, oncologists, pediatricians, and other clinicians from North America, Asia, and France cover the history of its treatment, its epidemiology and etiology, diagnosis and classification, molecular pathogenesis, cytogenetics, chemotherapy for adults and children, the use of asparaginase, the monitoring of minimal residual disease to guide therapy, prophylaxis and treatment of central nervous system involvement, pharmacogenomics and chemotherapy, hematopoietic stem cell transplantation, long-term complications of therapy, and new treatment agents, including bispecific T-cell engaging antibodies and autologous antigen receptor expressing T-cells.
Washington, Jan 19 ( ANI ): Scientists in Singapore have found that asparaginase (ASNASE) - the enzyme that degrades the amino acid asparagine and serves as a common chemotherapeutic agent - arrests Group A Streptococcus (GAS) growth in human blood and blocks bacteria's proliferation, thus initiating a new potential treatment against deadly Streptococcal infections.
To address these concerns, Novozymes introduced the asparaginase Acrylaway[R] in 2007, a product that is today used industrially in more than 30 countries in a wide range of consumer products such as biscuits, snacks and French fries.