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Secreted IL-1[beta] also acts in an autacoid manner, to engage IL-1[beta] receptors, activate the signaling molecule MyD88, and stimulate additional inflammatory reactions.
Autonomic & Autacoid Pharmacology23 (5-6): 319-26.
The distribution of histamine receptors means that responses to the autacoid vary in different vascular beds (1,144), making the site of injection of antigen or histamine releasing drug an important variable.