Contract notice: Open procedure for the provision of a diagnostic system for the assay of autoantibodies
using immunometric techniques.
Diagnosis for these disorders include blood tests for one or more autoantibodies
and tests for inflammation.
The measurement of specific autoantibodies
remains the most commonly employed IVD for autoimmune disease.
To investigate the molecular basis for DNA recognition by lupus autoantibodies
, antibody genes from a large number of human and murine anti-DNA antibodies from hybridomas have been characterized.
Cryoglobulins, anti-GM1 and anti-MAG autoantibodies
In past experiments, Utz has relied on homemade protein arrays to detect biomarkers such as autoantibodies
The pathogenesis of cicatricial pemphigoid involves a defect in immunoregulation and a resultant production of autoantibodies
that affect the basal membrane.
These autoimmune antibodies, or autoantibodies
, are made by immune B cells and appear to dispose of damaged pancreatic islet cells, says Hans-Michael Dosch, an immunologist at the Hospital for Sick Children in Toronto.
Additionally, in contrast to other diagnostic assays that rely on "Yes/No" determinations, the CombiChip uses an IgG concentration calibrator to quantitatively measure the presence of autoantibodies
for each single patient's sample.
Contract notice: Supply of reagents and laboratory tests for the diagnosis of autoantibodies
, antibodies against borrelia, matrix metalloproteinase 3, hla-b27 and the immune complexes using elisa immunoassay methods, indirect immunofluorescence, flow cytometry and immunoblotting for the laboratory department of rheumatology and internal medicine teaching hospital no.
Of note, the predictive power of islet-specific antibodies is strengthened by increasing the number of antigens tested, so serum autoantibodies
directed against insulin, glutamic acid decarboxylase, and protein tyrosine phosphatase are used to determine the risk of developing T1D and have been incorporated to the design of clinical trials in T1D (36,37).
A significant body of literature reports the presence of autoantibodies
against cancer antigens in the peripheral circulation of cancer patients--shown to be true in lung, breast, cervical, and colorectal cancers, among others.