Ascorbic acid stimulates gonadotropin release by autocrine
action by means of NO.
6) also mentioned that HRS cells are sustained by an autocrine
and/or paracrine production of several cytokines, including IL-5, IL-8, IL-9, CCL- 5, and CCL-28.
16,17) Ben-Josef and colleagues have proposed the presence of an FSH/FSH receptor (FSHR) autocrine
loop, postulating that FSH could stimulate the transition from a hormone-sensitive to a hormone-independent state.
While it was first identified and classically referred to as a highly coordinated endocrine system, recent research has identified the RAAS system as also being an autocrine
and paracrine system.
9) Increased oestrogen stimulation causes several autocrine
responses including the up-regulation of platelet-derived growth factor and the down-regulation of activin and myostatin levels which have a significant role in regulating myometrium cellular differentiation.
This is where things got interesting, because previous reports had indicated that LNCaP cells lack autocrine
SHH signaling capacity.
Ovulation rate is determined by a complex exchange of endocrine signals between the pituitary gland and the ovary and paracrine and probably autocrine
signals in ovarian follicles involving the oocyte and its adjacent somatic cells.
WISP1 (also known as CCN4) is an autocrine
and paracrine extracellular stimulus involved in several detrimental profibrotic processes.
Especially, the combined treatment with Baccharin and Drupanin, each used at an lC2o concentration, exhibited a significant synergistic growth-inhibitory effect through both intrinsic and extrinsic apoptotic signaling pathways, which effect was mediated by up-regulation of the levels of TRAIL and FasL, in the extrinsic pathway that function in an autocrine
or paracrine manner.
BMP-6 is an autocrine
stimulator of chondrocyte differentiation.
It acts in an endocrine, paracrine and autocrine
manner to promote growth.
Administration of Mobilan in animal models leads to constitutive autocrine
stimulation of TLR5 signaling causing strong induction of the innate immune system with subsequent development of adaptive anti-tumor immune responses.