autophagia

(redirected from autophagic)
Also found in: Medical.
Related to autophagic: autophagic vacuoles

autophagy, autophagia

Medicine. 1. the eating of one’s own body.
2. the nutrition of the body by its own tissues, as in dieting. — autophagous, adj.
See also: Food and Nutrition
References in periodicals archive ?
Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells.
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.
Additional roles in raising whole batteries of detoxification responses and autophagic removal of destructive protein aggregates and dysfunctional organelles may also be useful in disease prevention and treatment.
This subject has garnered intense interest recently with emergence that two genes linked to Parkinson~s disease, PINK1 and parkin, regulate the autophagic degradation of mitochondria (mitophagy).
It is possible that screening for mTOR and autophagic activity will provide a means to diagnose some features of autism, and normalizing these pathways might help to treat synaptic dysfunction and treat the disease.
Editor Hayat presents this first volume of a four-volume series on autophagic processes, with an introduction to the series giving a broad overview of autophagy in the healthy state and a selection of disease states.
Adds first author Anju Sreelatha, a graduate student in Orth's laboratory: "Disruptions of autophagic pathways are implicated in many human diseases, including neurodegenerative disease, liver disease, some cancers, and cardiomyopathy [heart muscle disease].
Poster title: Decline in mitochondrial function after autophagic stress in a human Parkinson's disease cell model.
p53 is a central cellular stress sensor that responds to multiple insults including oxidative stress and is known to orchestrate apoptotic and autophagic types of cell death.
Activation of autophagy using the mTOR inhibitor rapamycin has been shown to reduce mutant protein toxicity in models of HD and SCA3, suggesting that small molecules capable of inducing the autophagic cascade may be of therapeutic benefit.
Degradation of macromolecules in the senescent cell is mainly due to autophagic processes in the vacuole; protein degradation in mitochondria, nuclei, cytoplasm; fatty acid breakdown in peroxisomes and nucleic acid degradation in nuclei (Bieleski, 1995; Mahagamasekera & David, 2001; Wagstaff et al.
Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells.