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autoregulation |
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It is felt to result from loss of autoregulation to the intracranial blood supply, sometimes resulting in increased intracranial pressure and possible herniation (4). The disruption of vessels leads to intraparenchymal hemorrhage; the disruption of the blood-spinal cord barrier, which is closely associated with edema formation; the release of vasoactive molecules that influence the extent of spinal cord perfusion; and the loss of autoregulation. [26] In addition, because sluggish baroreceptor and sympathetic nervous system responsiveness as well as impaired cerebral autoregulation may be present in these patients, Langer et al[27] recommend that blood pressure goals be achieved over periods of months rather than days or weeks. |
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