Harper demonstrated that cerebral vasodilation secondary to hypercapnia can abolish autoregulation
and render the cerebral circulation pressure-passive (26).
will make a presentation titled: Autoregulation
and Vasoconstriction: Foundation for a New Generation of Blood Substitutes, at the American Society of Hematology (ASH) 44th Annual Meeting on Monday, December 9, 2002 at 9:00 a.
is impaired, then cerebral perfusion pressure is not maintained and cerebral blood flow can become pressure passive.
The initial response of the RV to an acute increase in PVR is to rapidly increase its contractile state (homeometric autoregulation
or Anrep effect).
The system, using a combination of electronic and fiberoptic technologies, displays clinical indices including autoregulation
status, vasoreactivity and cerebrovascular resistance, and is intended for use by neurosurgeons and neurosurgical intensive care specialists.
Eight participants reported planned noncompliance or autoregulation
of renal and splanchnic blood flow following infra-renal aortic clamping is mediated by nitric oxide and vasodilator prostanoids.
7,16,35,37] Both decreased intracranial compliance and impaired cerebral blood flow autoregulation
contribute to decreased intracranial adaptive capacity.
In early septic shock, autoregulation
of microcirculatory mucosal blood flow is largely intact and blood seems to be diverted from the muscularis towards the mucosa (11).
7,24] These conditions contribute to development of a cascade of cellular and metabolic alterations that eventually result in loss of cerebral autoregulation
, impaired perfusion, and ischemia.
In the majority of head-injured patients, CBF and metabolic rate are uncoupled due to loss of cerebral autoregulation
2,3,4] In addition, there is mounting evidence that autoregulation
remains intact in many cases of TBI.