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auxotroph

   Also found in: Medical, Wikipedia 0.01 sec.
aux·o·troph  (ôks-trf, -trf)
n.
An organism, such as a strain of bacteria, that has lost the ability to synthesize certain substances required for its growth and metabolism as the result of mutational changes.
[Back-formation from auxotrophic.]
auxotroph [ˈɔːksətrəʊf]
n
(Life Sciences & Allied Applications / Microbiology) a mutant strain of microorganism having nutritional requirements additional to those of the normal organism
auxotrophic  adj
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The yeast morphotype but not the mold, for example, has a cysteine dioxygenase activity and is a cysteine auxotroph.
Cellular, molecular and developmental biology by Journal of the Mississippi Academy of Sciences
With NS0, you get endogenous Ig processing pathways; no endogenous Ig (or fragment) secretion; auxotroph for cholesterol high levels required; extensive pedigree in regulatory approval; a long history of applications and successes; robust transfection and fusion applications; and high yields in cell culture and product expression.
Mammalian cell technology improving, expert notes; 1-4g/L realized ... by Pickett, Joseph / Validation Times
 
 
 
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