There are no clinical guidelines available for choice of antimicrobial therapy, various case reports have reported different antimicrobial therapies using monotherapy with a broad spectrum b-lactam
antibiotics like carbapenem or piperacillin-tazobactum or combination of an intravenous beta-lactam antibiotic with metronidazole.
Understanding and detecting b-lactam
antibiotics resistance and resistance genes and elucidating the drug-resistant mechanism is of significance to prevention and treatment of avian Escherichia coli disease.
1 Therefore, resistance to b-lactam
antibiotics through the acquisition of genes that encode b-lactamases is one of the most serious problems in Gram-negative pathogenic bacteria.
Shah and coworkers found that 95% of the isolates studied lacked mecA, which is the gene that confers B-lactam
In a large case series of pregnant women with listeriosis, most patients were given a b-lactam
antimicrobial drug, with or without gentamicin (6).
Spread of B-lactam
resistant Pseudomonas aeruginosa in cystic fibrosis clinic Lancet 1996; 348: 639-642.
Role efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to b-lactam
According to them, b-lactam
resistance is widespread among Coliform bacteria due to vertical as well as horizontally acquired resistance factors.
In approximately 73% of the patients, the infecting strain of MRSA was resistant to prescribed antibiotics, yet in patients with skin or soft-tissue infections, treatment with inappropriate antimicrobials (usually B-lactam
antibiotics) did not appear to correlate with differences in outcome (N.
This includes patients treated with a b-lactam
drug during the prior 30 days, those who are immunosuppressed, and patients admitted to the intensive care unit.
In particular, cephalosporin and carbapenem use correlates highly to subsequent infection with b-lactam
and/or carbapenem resistant Acinetobacter spp as a consequence of collateral damage in various studies.
Group 24 - Antibacterials B-lactam
antibiotics - penicillin susceptible to B-lactamase