Importantly, 16 of the 18 isolates were drug-susceptible (nonMDR), while 9 of the 18 bacteraemic
episodes occurred in HIV-seropositive children with clinical presentations compatible with AIDS.
11, 12) Thus, the incidence of bacteraemic
pneumococcal pneumonia has increased exponentially as the HIV epidemic has escalated in South Africa.
Although the studies have been retrospective or purely observational in design the benefit in outcome has been shown particularly in sicker, hospitalised patients with pneumonia, including the sub-set of patients with bacteraemic
In the case of the former, Mushner and colleagues reported that circulating antibodies to pneumolysin measured in adult patients with pneumococcal pneumonia at the time of hospital admission were highest and lowest in patients with non-bacteraemic
In a further timely reminder Brink and colleagues report on the antimicrobial susceptibility profile of selected bacteraemic
pathogens from private institutions in South Africa (p.
3] Inappropriate use can also result in the development of antibiotic resistance among bacteraemic
Influence of pneumococcal serotype group on outcome in adults with bacteraemic
Mortality following bacteraemic
infection caused by extended-spectrum beta-lactamase (ESBL) producing E.
Antimicrobial susceptibility patterns of selected bacteraemic
isolates from South African public sector hospitals, 2010.
Synflorix is a paediatric pneumococcal conjugate vaccine (PCV) aimed at delivering protection against invasive pneumococcal diseases, such as meningitis, bacteraemic
pneumonia and sepsis It also helps to provide protection against pneumococcal middle ear infection, otherwise known as acute otitis media (AOM).
patients were given medical care by different nursing staff.
pneumoniae also causes invasive diseases, which may manifest as bacteraemia (including cases of bacteraemic
pneumonia), meningitis, septic arthritis and peritonitis.