Massive thickening of basement membranes
has been associated with long term diabetic retinopathy and as a result of these morphological changes, the success rate of corneal transplant in diabetic patients is greatly affected12.
The antimicrobial and anti-inflammatory properties of AM, along with the similarity between the basement membranes
of AM and the oral mucosa, might make it a suitable alternative to a CTG.
Electron microscopy showed that foot processes of podocytes were partially effaced and basement membranes
were irregularly thickened.
Mucous membrane pemphigoid is a spectrum of bullae forming diseases that is characterized by deposition of subepithelial immunoglobulin with involvement of oral, ocular, nasal, nasopharyngeal, anogenital, skin, laryngeal, and esophageal basement membranes
1] Subsequently, development of diabetic nephropathy mesangial expansion and changes in the matrix of glomerular and tubular basement membranes
Mutations in these genes disrupt the normal function of type IV collagen present in basement membranes
of kidneys, ears, eyes and skin, thereby affecting their integrity.
The glands are of different sizes, many of them containing mucinous/amorphous debris and are surrounded by thick basement membranes
In this disease, there is formation and deposition of antibodies against the alpha-3 chain of type IV collagen along glomerular and alveolar basement membranes
A connective tissue, basement membranes
sit outside cells and are composed of ropes of collagen and other large molecules.
The irregular basement membranes
of seminiferous tubules were lined with one or two layers of small acidophilic cells with dark nuclei and several layers of degenerated cells, different germ cells especially mature sperms were not seen, in the seminiferous tubule whereas, hyaline necrotic areas were observed (Fig.
The glomerular basement membranes
(GBMs) are thickened, which, along with mesangial expansion, leads to decreased patency of capillary lumens and decreased ultrafiltration surface area.
The illustrated chapters include fixation and processing, microtomy, frozen sections, hematoxylin and eosin, Gram stain, myobacteria, Heliobacter pylori, spirochetes, fungi, trichrome stains, reticulin, elastin stains, basement membranes
, mucin stains, amyloid, and immunohistochemistry.