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beta-adrenergic receptor

   Also found in: Medical, Acronyms, Wikipedia 0.01 sec.
beta-adrenergic receptor
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Noun1.beta-adrenergic receptor - receptors postulated to exist on nerve cell membranes of the sympathetic nervous system in order to explain the specificity of certain agents that affect only some sympathetic activities (such as vasodilation and increased heart beat)
sympathetic nervous system - originates in the thoracic regions of the spinal cord; opposes physiological effects of the parasympathetic: reduces digestive secretions; speeds the heart; contracts blood vessels
receptor - a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response


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The primary beta-adrenergic receptor comes in several forms, the most common of which are arg389 and gly389.
[30] The reasons for these effects are not fully understood but are probably related to blockade of beta-adrenergic receptors located on fat cells, liver cells, and other tissues, thus causing disruption of catecholamine-mediated control of lipid and carbohydrate metabolism in these tissues.
In prior presentations, Cytokinetics scientists presented results that demonstrate that cardiac myosin activators increase cardiac contractility without increasing intracellular calcium and without stimulating beta-adrenergic receptors or inhibiting phosphodiesterase activity, mechanisms that may be arrhythmogenic and associated with other adverse clinical effects.
 
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