In addition, another drug being developed focuses on beta-secretase (BASE), a compound that makes it possible for beta-amyloid
Yet, even when scientists found ways to eliminate beta-amyloid
from the brains of people with AD, the disease continued to progress.
The drug, solanezumab, was designed to prevent beta-amyloid
from forming plaques in the brain, and early trials had suggested that it might achieve this aim.
SAN DIEGO, Calif, January 8, 2016 -- Investigators here have discovered that high sugar caused by Type 2 (adult-onset) diabetes and the beta-amyloid
protein associated with Alzheimer's disease induce the same pathological modification on multiple enzymes in the brain.
UCLA researchers have offered the first evidence that a simple blood test could confirm the presence of beta-amyloid
proteins in the brain, a hallmark of Alzheimer's disease.
PET scans using radio-labeled flutemetamol were safe to use in vivo and confirmed the presence or absence of neuritic beta-amyloid
levels "with high sensitivity and specificity" in a phase III trial involving 68 terminally ill older adults.
Using the system the laboratory developed, investigators from the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH) now provide the first clear evidence supporting the hypothesis that deposition of beta-amyloid
plaques in the brain is the first step in a cascade leading to the devastating neurodegenerative disease.
plaque build-up in the brain is a distinctive characteristic among AD patients.
The research focuses on the detection of beta-amyloid
, a protein which folds incorrectly and forms clumps in the brains of those with Alzheimer's; one of the hallmarks of the disease.
In two other studies, the level of beta-amyloid
detected in the eye was significantly correlated with the burden of beta-amyloid
in the brain and allowed researchers to accurately identify the people with Alzheimer's in the studies.
Deposits of beta-amyloid
plaques are one of the hallmarks of AD.
M2 EQUITYBITES-October 22, 2012-Lillya[euro](tm)s Amyvid Amyvid (Florbetapir F 18) solution recommended for approval in Europe as a diagnostic tool for PET Imaging of Beta-Amyloid
Plaque Density(C)2012 M2 COMMUNICATIONS http://www.