Ronald MB, Christopher DH (1990) A bradykinin
antagonist inhibits carrageenan edema in rats.
VIENNA -- The investigational bradykinin
receptor antagonist icatibant appears to hold considerable therapeutic potential in episodes of hereditary angioedema, Konrad Bork, M.
Combined action of vasoactive amines and bradykinin
mediates allergen-evoked thermal hyperalgesia in rats.
Unlike other treatments for HAE, FIRAZYR is the first bradykinin
receptor antagonist, offering a unique mechanism of action.
5), without affecting that induced by Substance P or bradykinin
Ra Pharma has discovered HAE drug candidates designed to prevent these attacks by inhibiting plasma kallikrein, which controls the release of bradykinin
, a mediator of swelling and pain associated with HAE attacks.
One year of perindopril also resulted in significant upregulation of the enzyme responsible for nitric oxide release, along with a 27% reduction in levels of angiotensin-II, a 17% increase in bradykinin
, and a significant reduction in tumor necrosis factor-[alpha].
The complete FAST-3 data demonstrates FIRAZYR's efficacy and safety further illustrating the utility of a bradykinin
B2 receptor antagonist to treat acute HAE attacks," said Dr.
Ecallantide produces rapid, specific, and reversible blockade of plasma kallikrein, by inhibiting the plasma kallikrein-mediated cleavage of high-molecular weight kininogen (HMWK), directly affecting the pathways involved in both the upstream mediators of bradykinin
production as well as the downstream mediators of degradation, thus preventing the release of bradykinin
has been shown to be elevated in HAE patients and responsible for edema formation during HAE attacks.
The protein encoded by the claimed sequences is thought to play a role in modulating bradykinin
and substance P levels in an individual as well as specifically a role in acquired or inherited angioedema or acute pancreatitis.
is a naturally occurring peptide in the blood and an increase in its levels within the blood causes a widening of spaces within the cell walls of blood vessels, and swelling/ oedema occurs.