bradykinin


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brad·y·ki·nin

 (brăd′ĭ-kī′nĭn, -kĭn′ĭn)
n.
A biologically active polypeptide, consisting of nine amino acids, that forms from a blood plasma globulin and mediates the inflammatory response, increases vasodilation, and causes contraction of smooth muscle.

[brady- + Greek kīnein, to move; see keiə- in Indo-European roots + -in.]

bradykinin

(ˌbrædɪˈkaɪnɪn; ˌbreɪdɪ-)
n
(Physiology) a peptide in blood plasma that dilates blood vessels and causes contraction of smooth muscles. Formula: C50H73N15O11
[C20: from brady- + Greek kin(ēsis) motion + -in]

brad•y•kin•in

(ˌbræd ɪˈkɪn ɪn, -ˈkaɪ nɪn)

n.
a peptide hormone that dilates blood vessels and increases capillary permeability.
[1945–50]
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References in periodicals archive ?
A novel mechanism for bradykinin production at inflammatory sites: diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens.
With regard to alternative pathways of bradykinin metabolism, the enzyme aminopeptidase P (APP) is of particular interest.
However, the team found that each receptor produces different signals; the one associated with bradykinin causing both hyperalgesia and persistent pain, whereas the one associated with substance P only caused hyperalgesia.
On the day of surgery the patient was given subcutaneous 30 mg icatibant (a bradykinin antagonist) one hour prior to the procedure as per the treating immunologist.
The kallikrein-kinin cascade is stimulated as a result of activated kallikrein (or Hageman factor/Factor XII and prekallikrein), or microbial proteases cleave off bradykinin directly from either high-molecular-weight or low-molecular-weight kininogen in the plasma (3-11,13) which causes pain and extravasation.
LPS, TNF-[alpha], BCR and Bradykinin are four representative stimuli, which respectively activate the NF-[kappa]B signalling pathways.
Two are located on the angiotensin II type 1 receptor gene; the third is on the bradykinin type 1 receptor gene.
Other considerations are that direct contact of the contrast agent with the endothelium of blood vessels may activate Factor XII; this substance in turn activates kallikrein; kallikrein activates bradykinin; bradykinin activates prostaglandin and the leucotrienes.
And because of lesser bradykinin effects, the risk is lower for angioede-ma, as ARBs have about a 10% incidence of angioedema, compared with ACE inhibitors," Dr.
Intralesional injection of vasodilators, such as bradykinin, pilocarpine, acetylcholine, 5-hydroxytryptamine, nicotine, or histamine, fails to produce vasodilation in the affected areas.