In this study, the effects of Tanshinone IIA (Tan IIA), one of the active ingredients of Salvia miltiorrhiza root, on the BBB and brain edema
after transient middle cerebral artery occlusion in rats were examined.
Cooper hypothesized that albumin may increase brain edema
, prompting the use of other agents that could contribute to mortality; that it may increase bleeding or cause more coagulopathy; or that it may be the result of hemodilution.
The open-label extension study is evaluating XERECEPT's long-term safety and tolerability as a new potential treatment for peritumoral brain edema
(PBE), or tumor-related brain swelling.
leads to change in mental status, stupor or lethargy, ataxia or loss of balance, and eventually coma.
Regional cerebral bloodflow in peritumoral brain edema
during dexamethasone treatment: A xenon-enhanced computed tomographic study.
Repeat MRI showed several irregular areas of enhancement in the left parietooccipital area associated with marked brain edema
, left-to-right shift, and mass effect (Figure 2).
Invasion of the brain parenchyma is usually associated with marked surrounding brain edema
and reactive gliosis (2).
Celtic Pharma"), a global private equity firm focused on late stage pharmaceutical assets, announces that it has completed a successful Phase I/II study of the investigational new drug Xerecept[R] (corticorelin acetate) in pediatric patients who are dependent on the steroid Decadron (dexamethasone) to treat peritumoral brain edema
associated with cerebral tumors.
Initial data show that THR-18 significantly decreases the occurrence of intracranial hemorrhage (ICH) and brain edema
in acute ischemic stroke (AIS) patients
Brain tissue injury and intracranial hematoma after brain injury may induce brain edema
and increased intracranial pressure.
Side effects that have been reported in patients receiving Gliadel Implant include seizures, intracranial infections, abnormal wound healing, and brain edema
Microscopy findings included signs of focal encephalitis and vasculitis, lymphocytic perivascular inflammatory infiltration, profound degenerative and necrobiotic changes of ganglion cells in the cerebral cortex, and signs of brain edema
, as well as parenchymal myocarditis (stromal edema, degeneration of myocytes, foci of myolysis, and fragmentation of myofibrils).