Xenobiotic-metabolizing enzymes (XMEs) are found in the liver, kidney, skin, olfactory epithelia, and bronchiolar
Viral antigen was detected in neurons in the brain, bronchiolar
epithelium and macrophages in the lungs, bile duct epithelium in the liver, and macrophages and lymphocytes in lymph nodes.
Immunohistochemical staining of NOS isoforms, PAI-1, [alpha]-SMA, IL-4, IL-13, and bFGF-positive cells in alveolar septa, as well as endothelial, myofibroblast, and smooth muscle cells in terminal bronchiolar
arteries, were quantified by stereology at 400 x magnification with an eyepiece systematic point-sampling grid with 100 points and 50 lines used to count the fraction of lines overlying the positively stained structures (27).
Normal parenchyma, including normal appearing pneumocytes and bronchiolar
metaplasia surrounding a tumor showed positivity for phospho-mTOR expression in only 25.
As an example of the benefits potentially associated with biomarkers for ILD, Krebs von den Lungen-6 (KL-6) is a high-molecular-weight glycoprotein antigen (classified as a MUC1 mucin), first described by Kohno et al in 1985, that in normal lungs is expressed mainly on type II pneumocytes and bronchiolar
epithelial cells, while only weakly in basal cells of the terminal bronchiolar
epithelium, a small number of middle layer cells of the bronchial epithelium, and serous cells of the bronchial gland.
From the pathophysiological point of view, respiratory failure occurs due to irreversible obstruction of the bronchiolar
Stem cells found along the surfaces of the airways (in the bronchiolar
epithelium) proliferate rapidly in mice after viral infection and migrate to sites of damage.
A slightly more invasive tool that also provides a wealth of information is bronchoscopy and bronchiolar
Constrictive bronchiolitis is a lung disease characterized by fixed airways obstruction and fibrosis of the distal airways or bronchioles, with extrinsic narrowing or obliteration of the bronchiolar
Lesions occur predominantly within the alveolar spaces but often involve the bronchiolar
lumen; hence, the condition was formerly called bronchiolitis obliterans organizing pneumonia.
A 67-year-old woman presented with dry eyes, dry mouth, intermittent polyarticular nonerosive arthropathy, bronchial and bronchiolar
involvement with bronchiectasis, peripheral sensory neuropathy, cryoglobulinemic vasculitis (IgM [kappa] paraprotein), pronounced hypergammaglobulinemia ([gamma]- globulin fraction, 28.
Its mRNA and protein were detected at the brush-border membrane of human bronchiolar
epithelial H441 cells (Medina et al.