Pattern of liver injury Proposed mechanism of injury Zonal necrosis Formation of cellular adducts, free radicals, neoantigens Toxic hepatitis Hapten formation Microvesicular steatosis Deficient [beta]-oxidation of fatty acids Macrovesicular steatosis Increased triglyceride synthesis, decreased egress Phospholipidosis Formation of lysosomal inclusions Hepatocanalicular cholestasis Inflammation, damage to bile canaliculi
Canalicular cholestasis Decreased membrane fluidity, [Na.
In 1922, Cushing proposed that hyperostosis was due to invasion of the bony canaliculi
by meningioma, with resultant new bone formation due to stimulated osteoblastic activity.
A polyclonal antibody directed against carcinoembryonic antigen (Quartett, Berlin, Germany) (which cross-reacts with biliary glycoprotein 1) stained bile canaliculi
formed by hepatocytes, the surface of the biliary epithelium of portal tracts and BDH, as well as the cytoplasm and membranes of scattered tumor cells.
47) CD10 is normally present on the surface of early lymphoid cells as well as on a number of other normal cell types, such as bile canaliculi
and renal and intestinal epithelial cells.
Preclinical studies suggest that serum aminotransferase elevations induced by bosentan and chemically-related compounds may be due to their direct competition with bile salts for active transport across the hepatocyte membrane into the bile canaliculi
Abdominal ultrasound showed no abnormal size of her liver nor any abnormalities of the biliary canaliculi
Key functional, hepatocyte-specific, morphological features such as biliary canaliculi
were maintained in the cells over this extended time period.
The lacrimal apparatus consists of two canaliculi
in the upper and lower eyelids that drain tears into the lacrimal sac and ultimately into the nose through the nasolacrimal duct.
When applied to properly functioning hepatic cells, B-CLEAR opens the bile pockets (analogous to bile canaliculi
in vivo), allowing material that has been transported from inside the cell into the bile pocket to be measured.
45-47) If no staining of the cotton tip is observed (negative result) this indicates lacrimal pump failure such as stenosis of the puncta or canaliculi
as no tear fluid entered the nasolacrimal sac prior to syringing.