Biomarker analysis of blood samples from patients with cancer treated with CYC202 demonstrated that 54% (14 of 26 analyzed) tested positive for cancer cell
death or apoptosis following single agent treatment with the drug.
Modulation of aromatase activity by growth factors in an androgen sensitive human prostate cancer cell
ARQ 197 is designed to block the activity of c-Met, a receptor tyrosine kinase that plays multiple key roles in human cancer, including cancer cell
growth, survival, angiogenesis, invasion and metastasis.
Clearly, these fatty acid diols stimulate breast cancer cell
proliferation in vitro and disrupt reproductive function in rats at relatively low concentrations.
ArQule's second cancer platform, Cancer Survival Protein modulation, has generated a clinical-stage product designed to inhibit a molecule known as c-Met, which plays multiple roles in cancer cell
growth, survival, invasion, angiogenesis and metastasis.
The discovery of CDKs and cyclins and their role in checkpoint control of the cancer cell
cycle has been honored with the 2001 Nobel Prize for Medicine and Physiology.
They screened a group of enzymes known as serine hydrolases by measuring the activity levels of these enzymes in normal prostate epithelial cells and in three standard prostate cancer cell
make cancer cell
membranes more fluid and pliable, enabling the cells to get out of small blood vessels and into the surrounding tissues;
Among this emerging group of breast cancer patients lies a second generation whose reactions to targeted therapies include a reduction in cancer cell
size that, it appears to doctors, cures the patient.
Researchers at Salk Institute used a small pipette to extract and analyze the RNA of individual breast cancer cells
to track a cancer cell
Often a mechanism for cancer cell
death, "self-eating," in this case, acts as a survival mechanism for dormant cancer cells
Amplimexon appears to kill cancer cells
by causing the disruption of mitochondria, the energy producing factories of the cancer cell
, resulting in the leakage of toxic substances which kill cancer cells