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cantharidin |
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| We also investigated the AhR-dependent activities of cantharidin and emodin (in herbal extracts) in Ah-responsive MCF-7 human breast cells, HepG2 human liver cancer cells, and mouse Hepa-1 cells transiently or stably transfected with plasmids expressing a luciferase reporter gene linked to multiple copies of a consensus dioxin-responsive element. One subject reported 5 prior treatments, including injection, cantharidin in acetone, and laser. Attending physicians noted that the symptoms resembled those seen in men who had overindulged in a drug called cantharidin -- popularly known as Spanish fly -- which is extracted from a particular beetle for its purported value as an aphrodisiac. |
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