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capsid |
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A heminested PCR targeting the major capsid protein gene was performed (3), amplicons were sequenced (SeqWright DNA Technology Services, Houston, TX, USA), and a GenBank BLAST search (www. Gelbart were struck by the fact that experiments dating back to the 1960s showed that viral capsids with icosahedral symmetry will form spontaneously in a solution of capsid proteins, given the right conditions of temperature, pH, and salinity. The difference is that protease inhibitors target the protease enzyme, while PA-457 uses other mechanisms (in technical language, it blocks release of the capsid protein). |
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