Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem
During the last five decades health care facilities around the globe have experienced the emergence of microorganisms like Methicillin resistant staphylococcus aureus (MRSA), Vancomycin resistant enterococcus (VRE), Extended spectrum beta lactamases (ESBL), Carbapenem
resistant Enterobacteriacae (CRE), Carbapenem
resistant Acinetobacter baumanni (CRAB) and many more antibiotic resistant microorganisms that microbiologists and clinicians have to memorize the alpha-betical acronyms and abbreviations.
-resistant Enterobacteriaceae (CP-CRE) express plasmid-encoded carbapenemases, enzymes that inactivate carbapenem
A total of five carbapenem
resistant bacterial species; E.
activiti against Pseudomonas aeruginos a: Respective contributions of OprD and efflux systems.
In this issue Julie Creighton and Clare Tibbs evaluated and compared the recently released MAST indirect carbapenemase test (ICT) and a modified carbapenem
inactivation method (mCIM) test to determine their ability to detect carbapenemase production, and to reliably 'rule out' a non-carbapenemase producer.
The screening for carbapenem
resistance was performed by meropenem and imipenem discs, and minimum inhibitory concentrations.
They become resistant to the carbapenem
antibiotics when they acquire a certain DNA molecule that is linked to a gene that produces carbapenemase, an enzyme that breaks down the antibiotics, rendering them ineffective.
The effect of different carbapenem
antibiotics (ertapenem, imipenem/cilastatin, and meropenem) on serum valproic acid concentrations.
resistance can be ascribed to several enzymes encoded by resistance genes including the production of various carbapenemases: K.
The epidemic of CRE began in the early 2000s with an outbreak of carbapenem
-resistant Klebsiella pneumoniae harboring K.
United States-based Pfizer's fixed-dose antibacterial combo, Zavicefta (ceftazidime-avibactam), has indicated a comparable cure rate in its phase three REPROVE study compared to carbapenem
antibiotic therapy, it was reported yesterday.