May 21, 2013 /PRNewswire/ -- Masimo(NASDAQ: MASI) announced today that a new clinical study posted online in Respiratory Care confirms the clinical utility of Masimo's noninvasive carboxyhemoglobin
Until now, pulse oximeters could only measure and display functional oxygen saturation (SpO2), so when patients had elevated carboxyhemoglobin
(from carbon monoxide poisoning) and/or elevated methemoglobin (negative reaction to more than 30 common drugs used in hospitals) the displayed functional oxygen saturation overestimated the actual oxygen saturation value.
Myocardial and systemic responses to carboxyhemoglobin
In reality, the test produces results that accurately reflect the condition of the membrane, as well as other related physiological factors such as hemoglobin and carboxyhemoglobin
Reddy measured carboxyhemoglobin
and methemoglobin levels using the Rad-57 Pulse CO-Oximeter (Masimo Corp.
He said Dominic had a 70% blood level of carboxyhemoglobin
CO interacts with deoxyhemoglobin and forms carboxyhemoglobin
The most characteristic sign of CO poisoning is a cherry color of the skin and mucous membranes due to the bright red color of carboxyhemoglobin
Carbon monoxide concentrations of 100 ppm to 200 ppm can generate carboxyhemoglobin
levels of approximately 10 percent to 20 percent, which trigger clinical symptoms such as headache, nausea, and mental impairment or confusion.
In 2005, Masimo introduced rainbow[R] SET Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously required invasive procedures, including total hemoglobin (SpHb[R]), oxygen content (SpOC), carboxyhemoglobin
(SpCO[R]), methemoglobin (SpMet[R]), and Pleth Variability Index (PVI[R]), in addition to SpO2, pulse rate, and perfusion index (PI).
Animal studies also revealed that tea filters could significantly reduce the acute toxicity, mutagenicity, lung damage and carboxyhemoglobin
(COHb) levels in the blood caused by cigarette smoking.
The prosecuting lawyers' case hinged on the measured carboxyhemoglobin
(COHb)  concentration to prove that the wife was indeed alive when the fire was started and therefore the husband was also guilty of murder by committing arson.