Secondly, candidate ligases, carboxylases
and the cognate acyltransferase domains that specifically recruit the unusual extender units will be studied in vitro for substrate specificity and for their ability to accept non-natural substrates bearing chemical functionality.
Biotin is known to play an essential role in metabolic pathways such as gluconeogenesis and fatty acid synthesis by acting as a prosthetic group for carboxylases
Differencial activation of recombinant human acetyl-CoA carboxylases
1 and 2 by citrate.
In humans, biotin is a coenzyme for 4 important carboxylases
in fatty acid synthesis, branched-chain amino acid catabolism, and gluconeogenesis (4, 5).
It is an important cofactor to several enzymes, including acetyl CoA carboxylase
and other carboxylases
Structural similarity and functional differences between invertebrate and vertebrate carboxylases
: expression and characterization of recombinant vitamin K-dependent [beta]-glutamyl carboxylase
from Conus textile.
Biotin is a cofactor in metabolic reactions which require carboxylases
Given the functional similarity of mammalian vitamin K-dependent carboxylases
and the vitamin K-dependent carboxylase
from Conus textile, we hypothesized that structurally conserved regions would identify sequences critical to this common functionality.
The current study suggests the presence of an association among milk production and genetic polymorphism in the exon I region of Acetyl Coenzyme A Carboxylase
a (ACACA) in Iranian indigenous Mahabadi goat.