As these scientists established laboratories and research agendas at the NIEHS, scientific interest in environmental mutagenesis increasingly converged with research on environmental carcinogenesis
In this review, we discuss biochemical properties of tocopherols, results of possible cancer preventive effects in humans and animal models and possible mechanisms involved in the inhibition of carcinogenesis
Trivalent dimethylated arsenic, which can be produced by the metabolic reduction of DMA, has attracted considerable attention from the standpoint of arsenic carcinogenesis
Scientists expect the animals also will be useful for testing the effectiveness of substances thought to protect against the development of cancer, and as a source of cells for experiments related to carcinogenesis
The Notice of Allowance for Callisto's SP304 was given for the patent titled, "Guanylate Cyclase Receptor Agonists for the Treatment of Tissue Inflammation and Carcinogenesis
In a hamster model of N-methyl-N-benzylnitrosamine (MBN)-induced oral carcinogenesis
, the incidence of buccal pouch (HBP) carcinomas in MBN-treated hamsters (17.
He and his coworkers are studying its effects on carcinogenesis
caused by different chemicals.
These results suggest that E2 metabolism and oxidant stress are critically involved in estrogen-induced breast carcinogenesis
," the authors conclude.
The Notice of Allowance was given for the patent entitled, "Guanylate or Guanylyl Cyclase Receptor Agonists for the Treatment of Tissue Inflammation and Carcinogenesis
The first half of fetal development is a period of very high sensitivity because of a high rate of cell proliferation, cell differentiation, and gene imprinting, all of which, when disrupted, can lead to carcinogenesis
While widely studied stilbenoids like resveratrol have shown antioxidant, anti-inflammatory, chemopreventive, and anti-aging effects in a number of biological systems, the purpose of this study was to identify the chemopreventive potential of pterostilbene with colonic tumor formation as an end point, and to further evaluate how pterostilbene affect colon carcinogenesis
In this model, designed to mimic human carcinogenesis
, telomere shortening, genetic instability, and chronic liver damage were engineered into telomerase positive and negative mouse strains.