Based on the histomorphologic findings, we established a diagnosis of carcinosarcoma
PGDx), a provider of advanced cancer genome analysis and testing services, and Blueprint Medicines, a leader in discovering and developing highly selective kinase inhibitors for genomically defined cancers, today disclosed the first-ever comprehensive genomic study of malignant mixed Mullerian tumors (MMMT), an aggressive and deadly cancer of the female reproductive system, also known as carcinosarcoma
Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma
and other uterine neoplasms.
Minor salivary gland carcinosarcoma
is a rare malignancy with an ominous prognosis.
1,2) It has been likened to carcinosarcoma
of the stomach, although it does not share the high-grade cytology or the dismal prognosis of carcinosarcoma
These studies support that the combination therapy delivered in a "sandwich" fashion is well tolerated and leads to better outcomes in the adjuvant treatment of both completely surgically resected uterine carcinosarcoma
(CS) and uterine papillary serous carcinoma (UPSC).
Classification of Metaplastic Carcinoma Proposed by the World Health Organization (a) Purely epithelial Squamous Large cell keratinizing Spindle cell Acantholytic Adenocarcinoma with spindle cell proliferation Adenosquamous, including mucoepidermoid Mixed epithelial and mesenchymal Carcinoma with chondroid metaplasia Carcinoma with osseous metaplasia Carcinosarcoma
(a) Data were derived from Tavassoli and Devilee, (20) 2003.
The differential diagnosis of cardiac SS includes carcinosarcoma
, malignant mesothelioma, leiomyosarcoma, hemangiopericytoma, and MPNST.
The trial will assess BSI-201, the first ADP-ribose polymerase (PARP) inhibitor in the company's DNA repair portfolio, for the treatment of uterine carcinosarcoma
or malignant mixed mullerian tumors.
1) This tumor has also been referred to as carcinosarcoma
, pseudosarcoma, spindle cell carcinoma, and polypoid carcinoma.
In the 2004 World Health Organization (WHO) classification, (2) sarcomatoid carcinoma is used as an overall term for a spectrum of tumors that includes pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma
, and blastoma.
Finally, a wide range of mullerian neoplasms are know to arise in association with endometriosis, including endometrioid and clear cell carcinoma, endometrial stromal tumors, adenosarcoma, and carcinosarcoma
(54,55); these diagnostic possibilities must be excluded in cases of extensive endometriosis.