Sales of Gliadel(R) Wafer (polifeprosan 20 with carmustine
implant) totaled $9.
The clinicians say Temozolomide and Carmustine
Implants are the biggest breakthroughs in the treatment of brain tumours for 30 years but the medicines have not received backing from the National Institute For Health and Clinical Excellence.
The proprietary Gliadel wafer contains a precise amount of the chemotherapeutic drug carmustine
The patient was started on six cycles of vincristine, carmustine
, and cyclophosphamide on the first day of treatment.
The wafer contains the cancer drug carmustine
and up to eight can be implanted in the cavity created when a tumour is surgically removed.
The most commonly used chemotherapy drugs have been alkylating agents, such as procarbazine (Matulane), temozolomide (Temodar), and the nitrosureas, carmustine
(BCNU) and lomustine (CCNU).
DTI-015 rapidly, thoroughly, and selectively saturates tumor tissue with significantly higher doses of carmustine
than are possible by other means.
In the first clinical trial, which included 222 patients at 27 medical centers, polymers containing the anticancer agent carmustine
, or BCNU, "significantly prolonged patient survival," says Brem.
But this oncology empire is built on a number of other drugs that were also invented through taxpayer-funded research, including cisplatin, carboplatin, carmustine
, and lomustine, to mention a few.
Each wafer contains carmustine
, a nitrosourea alkylating agent, distributed in a biodegradable polymer matrix.
About GLIADEL([R]) Wafer (polifeprosan 20 with carmustine
MGI PHARMA markets Aloxi([R]) (palonosetron hydrochloride) Injection, Dacogen([R]) (decitabine) for Injection, and Gliadel([R]) Wafer (polifeprosan 20 with carmustine
implant) in the United States.