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carnitine
(redirected from carnitine acetyltransferase)

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
car·ni·tine  (kärn-tn)
n.
A betaine commonly occurring in the liver and in skeletal muscle that functions in fatty acid transport across mitochondrial membranes.

[German Karnitin, from Karnin, a basic substance derived from meat, from Latin car, carn-, flesh; see carnal.]

carnitine  (kärn-tn)
A betaine commonly occurring in the liver and in skeletal muscle that is essential for fatty acid transport across mitochondrial membranes. Chemical formula: C7H15NO3.


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As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I.
In feeding studies in old rats, these mitochondrial metabolites and antioxidants improve the age-associated decline of ambulatory activity and memory, partially restore mitochondrial structure and function, inhibit the age-associated increase of oxidative damage to lipids, proteins, and nucleic acids, elevate the levels of antioxidants, and restore the activity and substrate binding affinity of a key mitochondrial enzyme, carnitine acetyltransferase.
Materials and methods Chemicals and reagents Berberine, ethylenediaminetetraacetic acid (EDTA), 2-aminofluorene (AF), N-acetyl-2-aminofluorene (AAF), dithiothreitol (DTT), Tris, acetylcarnitine, leupeptin, bovine serum albumin (BSA), phenylmethylsulfonylfluoride (PMSF), dimethyl sulfoxide (DMSO), acetyl-coen-zyme A (Acetyl-CoA) and carnitine acetyltransferase were obtained from Sigma Chemical Co.
 
 
 
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