caspase


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Related to caspase: Caspase 3, Caspase 9

caspase

(ˈkæspeɪz)
n
a type of enzyme that is involved in apoptosis and necrosis
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.caspase - any of a group of proteases that mediate apoptosis
peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
References in periodicals archive ?
This apoptosis was prevented by the non-specific caspase inhibitor z-VAD-fmk, and by the selective caspase-9 inhibitor z-LEHD-fmk.
Synthesis rate measurement of this Caspase in cells and its gene expression indicates apoptosis activation or deactivation.
If there were a therapeutic way to express, deliver, or induce caspase 4 and 5, humans would not get Legionella infection.
Measured responses included activation of ERK and JNK, mitogen-activated protein kinases involved in cell growth, proliferation, and apoptosis (programmed cell death); activation of caspases 8 and 9, enzymes that also are involved in apoptosis; and release of prolactin, a hormone that helps regulate hundreds of biological functions, including metabolism, reproduction, and lactation.
Various methods to inhibit apoptosis including the cell surface Fas receptor (FAS) pathway inhibitors (also known as CD95L pathway inhibitor), caspase inhibitors, overexpression of anti-apoptotic genes and small interfering ribonucleic acid (RNA) therapy are discussed.
Levels of caspase protein made by the dying coral shot up to six times normal levels, while levels of the protein dropped in the heat-resistant coral.
It also exerts its proapoptotic function via its protease activity, independent of IAP and caspase.
From the SCOP database it was found that all the caspase-3 proteins belongs to alpha and beta proteins and they are in the caspase catalytic domain family.
Efforts to prevent excessive lymphocyte apoptosis during severe infection have focused either on modification of the signal processing system to create an inherent bias against the triggering of cell death pathways or on inhibition of caspase activity to block their execution.
Wieckowska and her associates evaluated a caspase activity blood test in 44 consecutive patients with suspected NAFLD.
CV1013 is a member of one of several novel families of caspase inhibitors identified to date by Maxim through its proprietary apoptosis drug discovery program.
The signaling pathway induced by extracellular challenge with A[beta]1-42 involved activation of p53, BAX, cytochrome c, and caspase 3; as demonstrated by immunopositive pyramidal neurons stained by primary antibodies for each of the antigens.

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