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Related to cathepsin: Cathepsin C


Any of various enzymes found in animal tissue that catalyze the hydrolysis of proteins into smaller proteins.

[German Kathepsin, from Greek kathepsein, to digest : kat-, kata-, cata- + hepsein, to boil.]


(Biochemistry) a proteolytic enzyme responsible for the autolysis of cells after death
[C20: from Greek kathepsein to boil down, soften]


(kəˈθɛp sɪn)

any of a class of intracellular enzymes that break down protein in certain abnormal conditions and after death.
[1925–30; < Greek kathéps(ein) to digest]
ca•thep′tic (-tɪk) adj.
References in periodicals archive ?
Cathepsin K-dependent toll-like receptor 9 signalling revealed in experimental arthritis.
The inheritance is autosomal recessive and the point of mutation is the gene for cathepsin C (CTCS), a lysosomal protease, which lies on chromosome (11q14-q21).
In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D.
Ultraviolet A enhances cathepsin L expression and enzymatic activity
In the phytophagous insect, Colorado potato beetle, molecular complex interactions take place between the insect and the plant observing the "Red Queen hypothesis"; the food protein digestion is initiated by cathepsin D aspartic peptidase (Brunelle et al.
O'Donoghue, a cardiovascular medicine specialist at Brigham and Women's Hospital, noted in her presentation that "preclinical data suggested that inhibition of cathepsin K may reduce atherosclerosis progression and promote plaque stability.
6) leupeptin, 1 mM phenylmethylsulfonyl fluoride (PMSF)], and Anally a cathepsin buffer [50 mM Tris-HCl pH 7.
The report provides comprehensive information on the Cathepsin S (EC 3.
NFATc1 translocates to the nucleus and induces the expression of multiple osteoclast markers, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K, and cellular tyrosine protein kinase-Src (c-Src) (Boyle et al.
Rather than focus on a known factor, we did a screen for proteins that could be secreted by muscle tissue and transported to the brain, and among the most interesting candidates was cathepsin B," says senior author Henriette van Praag, a neuroscientist at the National Institute on Aging in the United States.
Another proteinase that has been implicated in COPD pathogenesis is cathepsin S, a lysosomal acidic proteinase which is highly expressed by cells implicated in COPD pathogenesis including macrophages and dendritic cells [6].