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cathepsin

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.03 sec.
ca·thep·sin  (k-thpsn)
n.
Any of various proteolytic enzymes found in animal tissue that catalyze the hydrolysis of proteins into polypeptides.

[German Kathepsin, from Greek kathepsein, to digest : kat-, kata-, cata- + hepsein, to boil.]

cathepsin [kəˈθɛpsɪn]
n
(Life Sciences & Allied Applications / Biochemistry) a proteolytic enzyme responsible for the autolysis of cells after death
[from Greek kathepsein to boil down, soften]


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Flatworms taken from mice treated with the drug showed reduced activity of the cysteine protease called cathepsin B, suggesting that this enzyme is a prime target of K11777.
Neutrophils exhibit defective chemotaxis and reduced intracellular killing for up to 90 minutes after bacterial phagocytosis, and their granules lack the serine proteases cathepsin G and elastase because of a failure of normal protein sorting (68,69).
Since papain is closely related to cathepsin B, a thiol endopeptidase which is released by cells of the inflammatory response, the authors concluded that segmented poly-etherurethanes can be degraded by enzymes which are present during the inflammatory response.
 
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