According to an NPPA notification, the prices of formulations, including Ciprofloxacin Hydrochloride, Cefotaxime
, Paracetamol, Domperidone and Metformin+ Glimepiride, have
belongs to the third generation of Cephalosporin and we considered it as a drug model because of its wide-spectrum of antimicrobial activity and its excellent water solubility .
Rapid identification of ESBL producers is possible by using the ESBL Nordmann/Dortet/Poirel (NDP) test (9), which is based on the biochemical detection of the hydrolysis of the b-lactam ring of cefotaxime
(a broad-spectrum cephalosporin).
One vial was removed just before antibiotic susceptibility testing and 5 [micro]l of clavulunate solution was added to the cefotaxime
(30 [micro]g) disc (Hi-Media, Mumbai).
Blood and urine cultures were obtained and empirical cefotaxime
200 mg/kg/day were initiated.
Extended-spectrumbeta-lactamase mediated resistance was assessed by disc diffusion method of four antibiotics ceftazidime, cefpirome, cefpodoxime and cefotaxime
and corresponding disc containing ceftazidime/clavulanic acid, cefpirome/clavulanic acid, cefpodoxime/clavulanic acid and cefotaxime
All strains were susceptible to ampicillin, cephalothin, cefotaxime
, enrofloxacin, nalidixic acid, gentamicin, streptomycin, chloramphenicol, fosfomycin, tetracycline, nitrofurantoin, and trimethoprimsulfamethoxazole.
We immediately changed the antibiotic treatment to cefotaxime
2x4 g IV per day.
is excreted via saliva, bile and mucus into throat and gut, and has been shown to eradicate carriage of 'normal' potential pathogens such as S pneumoniaa S.
Patients in the antibiotic group received 2 days of intravenous therapy consisting of cefotaxime
2 g twice daily and tinidazole 0.
Intraoperative and postoperative intravenous cefotaxime
Amoxicillin, ampicillin, cefepime, cefotaxime
, ceftriaxone, cefuroxime, ertapenem, imipenem, and meropenem must be tested by a MIC method.