centromere


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cen·tro·mere

 (sĕn′trə-mîr′)
n.
The most condensed and constricted region of a chromosome, to which the spindle fiber is attached during mitosis.

cen′tro·mer′ic (-mĕr′ĭk, -mîr′-) adj.

centromere

(ˈsɛntrəˌmɪə)
n
(Genetics) the dense nonstaining region of a chromosome that attaches it to the spindle during mitosis
centromeric adj

cen•tro•mere

(ˈsɛn trəˌmɪər)

n.
a structure appearing on the chromosome during mitosis or meiosis, where the chromatids are joined in an X shape.
[1920–25]
cen`tro•mer′ic (-ˈmɛr ɪk, -ˈmɪər-) adj.

cen·tro·mere

(sĕn′trə-mîr′)
The region of the chromosome to which the spindle fiber is attached during mitosis. The centromere is where the chromatids join together in pairs before separating into individual chromosomes. See more at meiosis, mitosis.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.centromere - a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape; "the centromere is difficult to sequence"
anatomical structure, bodily structure, body structure, complex body part, structure - a particular complex anatomical part of a living thing; "he has good bone structure"
chromosome - a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"
Translations
centrómero
tsentromeer
References in periodicals archive ?
Successful CGH was indicated by (1) the presence of 4',6'-diamidino-2-phenylindole (DAPI)-stained centromere regions, indicating adequate blocking by cot-1 DNA, (2) high fluorescence intensity for both fluorochromes, (3) high signal-to-noise ratio, (4) homogeneous appearance of the fluorescence without granularity, and (5) dark background of the image.
The Y-chromosome probe is highly specific for the repeated alphoid DNA located at the centromere of human chromosome Y, while the X DNA probe hybridizes to the short repeats related to the AATGG in the pericentric heterochromatin of the X chromosome.
Gene numbering starts from centromere to telomere on chromosome 19813.
The Y-chromosome probe is highly specific for the repeated alphoid DNA located at the centromere of the human chromosome Y, while the X DNA probe hybridizes to the short repeats related to the AATGG in the pericentric heterochromatin of the X chromosome.
Southern hybridization of DNA trapped on a filter by slot-blot makes it possible to estimate telomere amounts from whole cells, using standardization by the ratio of telomere to centromere DNA content (15).
With the probes used, each green spot corresponded to the centromere of a single chromosome 9, and each red spot corresponded to the specific probe for MYCC or MYCN (Figure 1, A and B, respectively, and Figure 2).
a) IIF pattern on HEp-2000 IIF pattern on HEp-2 Homogeneous Speckled Centromere Nucleolar Homogeneous 67 2 1 2 Speckled 5 49 0 2 Centromere 0 0 11 0 Nucleolar 0 0 0 6 (a) Values indicate number of samples that produced a particular fluorescence pattern.
FISH using a centromere probe for chromosome 4 was used as a negative control, because this chromosome is not commonly seen as aneusomic in prostate carcinoma or prostatic tissues.
Interestingly, using a satellite probe for the 17 centromere, we found that these 2 cases were mono-zygous for chromosome 17q, whereas most of the other samples were diploid or polyploid (data not shown).
This mixture was designed to allow assessment of the 11q13 locus and the chromosome 11 centromere (D11Z1).
In FISH analysis, the use of a reference gene near the centromere of chromosome 17 can differentiate between gene amplification and polysomy of chromosome 17 (10, 31).