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Related to cephalosporinase: penicillinase


 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
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Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions


a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
References in periodicals archive ?
Only the use of cloxacillin-containing Mueller-Hinton agar plates (200 [micro]g/mL) to inhibit the activity of the naturally occurring cephalosporinase (AmpC) allowed detection of a synergy image, signature of the presence of an ESBL (5).
chromosomal AmpC cephalosporinase induction/derepression or porin modification) as the basis in Enterobacter species.
cephalosporinase inhibited by clavulanic acid; carbapenemases inhibited by clavulanic acid) Oxacillin-hydrolyzing, OXA; cloxacillin; ESBL cephalosporins; weak activity for carbapenems (e.
aeruginosa is an inducible cephalosporinase that confers resistance to all betalactams except the carbapenems.
alteration of penicillin binding site, beta-lactamase and extended-spectrum beta-lactamase-producing organisms via chromosomal-inducible enzymes and cephalosporinase, ribosomal site alteration, efflux mediated mef E (high level) and target modifiable erm AM mediated (low level) resistance, alteration in the binding site of a specific transpeptidase (mec A) in methicillin-resistant S.
Penicillin and cephalosporins are not recommended for initial treatment due to the demonstration of a cephalosporinase and an inducible penicillinase in the anthrax genome.
The susceptibility pattern with regard to cefepime probably reflects excellent activity against chromosomal-located cephalosporinase (Amp-C)-producing isolates.
The DDST was also performed on MH agar plates (bioMerieux) containing cloxacillin (150 mg/L) to inhibit cephalosporinase activity of natural producers of those inducible cephalosporinases.
The Carba NP test perfectly differentiates carbapenemase producers (Table 1) from strains that are carbapenem resistant due to non-carbapenemase-mediated mechanisms, such as combined mechanisms of resistance (outer-membrane permeability defect associated with overproduction of cephalosporinase and/or extended-spectrum P-lactamases) or from strains that are carbapenem susceptible but express a broad-spectrum [beta]-lactamase without carbapenemase activity (extended-spectrum [beta]-lactamase, plasmid and chromosome-encoded cephalosporinases) (Table 2).
NDM-1] gene are diverse and can harbor a high number of resistance genes associated with other carbapenemase genes (oxacillinase-48 [OXA-48] types, VIM types), plasmid-mediated cephalosporinase genes, ESBL genes, aminoglycoside resistance genes (16S RNA methylases), macrolide resistance genes (esterase), rifampin (rifampin-modifying enzymes) and sulfamethoxazole resistance genes as a source of multidrug resistance and pandrug resistance (16,17) (Figure 2, panel B).