Previous products liability cases implicating statins have famously involved cerivastatin
(Baycol), a one-time rival to Lipitor, for causing rhabdomyolysis.
The synthetic cholesterol lowering statins such as fluvastatin (III) (Deslypere 1995), cerivastatin
(Mc CleIlan and Lynda 1998) were synthesized on the basis of natural product lead, that is, mevastatin (IV) (Yamamoto et al.
reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells.
For example, the cholesterol-lowering drugs cerivastatin
, lovastatin, pravastatin and fluvastatin are all in Class X.
Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin
Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin
In vitro data suggests that the rank order of cytotoxicity is starts with pravastatin as least toxic, followed by rosuvastatin, pitavastatin, lovastatin, atrovastatin, fluvastatin, simvastatin, and cerivastatin
as the most cytotoxic statin.
The route from acetoacetyl-CoA to 7-dehydrocholesterol (Figure 1) (7) is the very route inhibited by HMG-CoA reductase inhibitors, namely the statin drugs atorvastatin, cerivastatin
(withdrawn 8/01), fluvastatin, lovastatin, pravastatin, simvastatin, pitavastatin, and rosuvastatin, which were introduced to lower total cholesterol (TC) levels, and especially LDL-cholesterol (LDL-C) levels, ostensibly to prevent CVD.
14) Examples of international drug withdrawals have included fulminant liver failure with troglitazone, QT prolongation and ventricular arrhythmias with cisapride, haemolytic anaemia, coagulopathy and renal or hepatic dysfunction with temafloxacin, and fatal rhabdomyolysis with cerivastatin
For example, such popular and widely prescribed drugs as troglitazone, cerivastatin
, rofecoxib, valdecoxib, and cisapride were withdrawn from the market.
As expected, the fat-soluble statin, cerivastatin
, affected the placenta resulting in reduced growth but the researchers also found that pravastatin - the water-soluble statin thought to be potentially compatible for use in pregnancy - had the same detrimental effect.
Influence of coenzyme QUO) and cerivastatin
on the flow-mediated vasodilation of the brachial artery: results of the ENDOTACT study.