cerulein


Also found in: Medical, Wikipedia.

cerulein

(sɪˈruːliːɪn)
n
a bright blue dyestuff obtained from indigoa drug that stimulates smooth muscle and increases digestive secretions
References in periodicals archive ?
Acute pancreatitis was induced in rats in groups 3 and 4 with the infusion of glycodeoxycholic acidinto the biliopancreatic canal and infusion of cerulein parenterally.
Subsequently, cerulein (Sigma & Aldrich Chemie, GmbH, C-9026) was infused for 6 h, 5 [micro]g/kg per hour, with the infusion pump.
2]S, n=13): Like group 3, after acute pancreatitis was formed, 8 mL/kg/h serum physiologic and 5[micro]g/kg cerulein was infused; 8 mL/kg Ringer's lactate was infused for the remaining 18 h.
99-101) Mice deficient in T7 trypsinogen exhibit a marked reduction in activation of trypsinogen but nevertheless exhibit comparable levels of acute and chronic experimental pancreatitis induced by repeated injections of cerulein, a cholecystokinin receptor (CCKR) agonist as observed in wild type mice.
In initial studies designed to clarify the immune responses against intestinal microflora that might be playing a role in acute pancreatitis Watanabe and his colleagues subjected mice deficient in various innate immune receptors to experimental pancreatitis induced by repeated administration of relatively high doses of cerulein (50 [micro]g/kg), the latter an agent that causes pancreatitis via excessive stimulation of the CCKR.
Xu and colleagues (2015) reported using this model in mice exposed to alcohol and given injections of cerulein.
These scientists developed an in vitro experimental model that allowed them to evaluate how changes in the membrane fatty acid composition in vivo -caused by a change in the type of fat ingested- affect the ability of cells to respond to induced oxidative-inflammatory damage with cerulein (acute pancreatitis).
Similarly, cftr(-/-) mice showed constitutive expression of proinflammatory cytokines and developed more severe pancreatitis episodes after cerulein stimulation (22).
Furthermore, more severe pancreatitis attacks were observed after cerulein stimulation in cftr(-/-) mice (22).
9% wt/vol saline or saline containing 50 [micro]g/kg body wt of cerulein (Sigma-Aldrich, St.
5 [micro]M cerulein for 1 hour at 37[degrees]C [27, 28] after which the acinar cells were subjected to ROS assay, RNA isolation for quantitative real-time PCR analysis, and protein extraction for western blot analysis, respectively.