The research, led by Professor Douglas Fearon, determined that this barrier is created by a chemokine
protein, CXCL12, which is produced by a specialised kind of connective tissue cell, called a carcinoma-associated fibroblast, or CAF.
29, 2013 /PRNewswire/ -- TaiGen Biotechnology Company, Limited ("TaiGen") announced the results from the US Phase IIa trial of TG-0054, a CXC chemokine
receptor 4 (CXCR4) antagonist, in stem cell transplantation will be presented in an Oral Session at the 55th ASH Annual Meeting and Exposition (December 7-10, 2013) in New Orleans, LA, U.
Through some difficult laboratory techniques, we found that these genes were instructing the chemokine
Nasdaq:CCXI) has announced publication of positive data from the company's Phase 2 CARAT-2 study for CCX354, a potent and selective, orally-administered inhibitor of CCR1, a chemokine
receptor that drives the recruitment of inflammatory cells into the joints of patients with rheumatoid arthritis (RA).
The stromal-derived factor 1/CXC chemokine
receptor 4 (SDF-1/CXCR4) chemokine
receptor pathway has been identified as playing an important role in tumor development and metastasis in carcinomas of the breast, prostate, colon, lung, pancreas, ovary, and thyroid.
receptor 5 (CCR5) is a protein that belongs to the beta]-chemokine
receptor family and is expressed primarily on T cells, macrophages, and dendritic cells.
This work summarizes the growing body of evidence that several chemokine
receptors contribute to tumor cell migration as well as cell survival and proliferation.
Joon Feng and colleagues identified CXCR4, a receptor for the CXC chemokine
stronal cell-derived factor 1 (SDF1), as the long sought coreceptor for T-tropic HIV-1 strains (3).
Mountain View, CA), a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing therapeutics that target the chemokine
system, announced the publication of data from a series of rigorous experiments to elucidate CXCR7's essential role in the progression and development of certain cancers.
a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally-administered therapeutics that target the chemokine
system, announced that data from the company's Phase 2 clinical trial of Traficet-EN(R) (CCX282-B), targeting the chemokine
receptor CCR9, will be presented at the upcoming Digestive Disease Week (DDW) meeting in Washington D.
Subjects receiving subcutaneous administrations of CTCE-0214 did, however, experience transient injection site reactions and local pain after single and repeated administration of the drug, Chemokine
By administering an effective dose of a specific neutralizing agent for chemokine
CXCL10, and thus promoting the histological and functional repair of hepatic cells, we hope to offer a treatment that will improve the quality of life of patients who suffer from acute liver failure.