The chimeraplast, a combination of selected DNA and RNA--the chemical that translates the DNA's genetic code into a protein which the body can use--acts like a chemical instruction to the cell itself to alter the gene in the desired way.
Once we know the sequence of the gene, then we build the chimeraplast so it binds to the exact location where we want to make a change," Messerschmidt said.
drug works by using the gene repair machinery normally present in all cells, repairing the gene, thereby correcting the disease.
When used in clinical applications, this molecule is packaged with a delivery system and then is administered into the subject and ultimately the chimeraplast binds selectively to the portion of the target gene to be modified.
For plants, the chimeraplast enters a plant cell, makes the desired genetic change, and the modified cell is then grown into a full plant that contains the new trait, which is passed to the next generation through the seed.
serves as a template for alteration or repair of the gene sequence, following which the chimeraplast
is fully metabolized.
The researchers at Thomas Jefferson introduced the chimeraplasts into
sequence of nucleotide bases that the chimeraplasts target in the beta
suggesting that the chimeraplasts used in this study selectively acted