chlorambucil


Also found in: Thesaurus, Medical, Wikipedia.

chlorambucil

(klɔːˈræmbjʊsɪl)
n
(Pharmacology) an alkylating drug derived from nitrogen mustard, administered orally in the treatment of leukaemia and other malignant diseases. Formula: C14H19Cl2NO2
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.chlorambucil - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer
alkylating agent - an antineoplastic drug used to treat some forms of cancer
Translations

chlorambucil

n. clorambucil, forma de mostaza nitrogenada usada para combatir algunas formas de cáncer.

chlorambucil

n clorambucilo
References in periodicals archive ?
North Chicago, Illinois-based global biopharmaceutical company AbbVie (NYSE: ABBV) has released three-year follow-up data from the RESONATE-2 study which found that previously-untreated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients reported sustained improvements in measures of well-being with Imbruvica (ibrutinib) versus chemotherapy with chlorambucil, the company said.
Among these, the high-risk group is associated with an overall 80% chance of premature ovarian failure (POF) which mostly comprises alkylating agents such as cyclophosphamide (CYP), busulfan and chlorambucil.
Contract notice: Medicinal products containing cyclophosphamide, Chlorambucil, Melphalan and ifosfamide.
Cyclophosphamide, chlorambucil, intravenous tacrolimus, mycophenolate mofetil and thalidomide have also been found to be effective in a limited number of patients refractory to other therapies.
Other drugs that have been used less successfully are methotrexate and chlorambucil (10).
The drug used for indolent cases was chlorambucil with or without prednisolone, while for aggressive cases CHOP regimen was given.
The investigation is with regard to the company's pricing practices for niche medicines including the active pharmaceutical ingredients chlorambucil, melphalan, mercaptopurine, tioguanine and busulfan.
27) A Pekin duck (Anas platyrhvnchos domesticus) with lymphocytic leukemia treated with vincristine, prednisone, and chlorambucil had similar clinical signs and died 1 month after initiation of treatment.
Chemotherapy regimens used were FC in 38 (83%), FCR 5(11%), chlorambucil 2(4%) and CVP in 1(2%) patient.
Chlorambucil has been associated with the following side effects: bone marrow suppression; opportunistic infections and sterility.
For example, in a study on 'Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia' [1], the primary question is to find the treatment difference between ibrutinib and chlorambucil for 'previously untreated older patients with CLL or small lymphocytic lymphoma'.
8-10) Other medications are Methotrexate, Azathioprin and chlorambucil hydroxychloroquine.