Modifications of antidiabetic drugs in patients with type 2 diabetes mellitus (adapted from the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines) Class Drug Dosing recommendation stages 3 and 4 CKD or kidney transplant First-generation Acetohexamide, Avoid sulfonylureas tolazamide, tolbutamide Chlorpropamide
Avoid when GFR < 50 mL/min/ 1.
Phenacetin, paracetamol, metacetamol, oleanolic acid, tolbutamide, chlorpropamide
, furafylline, dextromethorphan, 6[beta]-hydroxytestosterone, glucose 6phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and tris (hydroxymethyl) aminomethane hydrochloride (Tris-HCl) were purchased from Sigma Chemical Co.
Pharmaceuticals include a class of oral medications used to stimulate the beta cells to release more insulin, such as sulfonylureas, meglitin ides, and chlorpropamide
The administration of the insulin secretagogue drug chlorpropamide
in fish leads to the hypoglycaemic effects (Al-Salahy, 2003) and insulin injections into fish also induced hypoglycaemia (Ottolenghi et al.
In contrast, patients receiving chlorpropamide
or glibenclamide gained an average of 3 to 4 kg, while insulin treated patients gained approximately 6 kg.
First generation sulfonylureas, like chlorpropamide
, should generally be avoided due to active metabolites and hypoglycemia risk.
The first-generation sulfonylureas currently available are chlorpropamide
(Di-abinese), tolazamide (Tolinase), and tolbutamide (Orinase).
The program, which begins July 29, includes the medications Glimepiride, Glipizide, Glyburide, Metformin and Chlorpropamide
which were previously available on the supermarket retailer's $4 prescription program.
Glibenclamide ou chlorpropamide
en traitement d'un diabete de type 2 (risque d'hypoglycemie prolongee).
In the non-tumoral causes of SIADH, like head trauma, pneumonia, and chlorpropamide
therapy, the plasma and urinary AVID concentrations are generally within normal ranges (16).
, carbamazepine and clofibrate are similarly used albeit less frequently.
1%; n = 1 909) as monotherapy, compared to other oral antidiabetic medicine used for monotherapy; followed by chlorpropamide