Although BDL is a model for acute obstructive cholestasis
, control mice survived up to 6 weeks after surgery, in agreement with previous results [19, 20].
No one particular class of drugs or mechanism of action is specifically associated with DILI, and many liver diseases are known to cause increased liver function levels (eg, viral hepatitis, acute cholestasis
, biliary tract disorders, and liver cirrhosis), making DILI challenging to detect (Figure 1).
A liver profile test panel showed mild increases in transaminases, increased alkaline phosphatase activity, hypoalbuminemia, significant hyperbilirubinemia, and evidence of cholestasis
with increased bile acids in the blood.
is probably due to toxicity at the level of the canaliculus, probably involving transporter molecules.
In some predisposed women, the metabolic changes are adequately severe to lead to development of gestational disorders of pregnancy including gestational diabetes mellitus (GDM) and intrahepatic cholestasis
of pregnancy (ICP).
In December 2012, three premature infants with cholestasis
hospitalized in Washington, DC, experienced erosive dermatitis in the diaper area and blisters on their extremities, a condition that can be associated with zinc deficiency (1).
After poisoning in animal with this toxicant lentadenes causes cholestasis
which undergoes photochemical reactions on exposure to sunlight, which causes photosensitization and associated skin lesions.
It demonstrated marked cholestasis
and a paucity of bile ducts (Figs 1 and 2).
ClickPress, Thu May 09 2013] GlobalData's clinical trial report, "Cholestasis
Global Clinical Trials Review, H1, 2013" provides data on the Cholestasis
clinical trial scenario.
PNALD is an umbrella term that encompasses several conditions, including cholestasis
, which results from a buildup of excess bile acids in the liver, and steatosis, which--as its "fatty liver" nickname implies--occurs when there is too much fat in the liver.
The results suggest for the first time that the use of miroestrol and deoxymiroestrol-containing products as alternative medicines or health supplements should be concerned according to their effects on key genes that regulate the bile salt export pump, which could result in the risk of hepatotoxicity and intrahepatic cholestasis
Alagille syndrome, and progressive familial intrahepatic cholestasis