cholestasis


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cho·le·sta·sis

 (kō′lĭ-stā′sĭs)
n.
Suppression of biliary flow.

cho′le·stat′ic (-stăt′ĭk) adj.

cholestasis

(ˌkəʊlɪˈsteɪsɪs)
n
(Pathology) the medical condition characterized by the inability of bile to pass normally out of the liver due to blockage or impairment

cho•le•sta•sis

(ˌkoʊ ləˈsteɪ sɪs, -ˈstæs ɪs, ˌkɒl ə-)

n.
impairment of the flow of bile.
[1930–35]
cho`le•stat′ic (-ˈstæt ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cholestasis - a condition in which little or no bile is secreted or the flow of bile into the digestive tract is obstructedcholestasis - a condition in which little or no bile is secreted or the flow of bile into the digestive tract is obstructed
disorder, upset - a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"
Translations

cho·le·sta·sis

, cholestasia
n. colestasis, estasis biliar.

cholestasis

n colestasis f; intrahepatic — of pregnancy colestasis intrahepática del embarazo
References in periodicals archive ?
Although BDL is a model for acute obstructive cholestasis, control mice survived up to 6 weeks after surgery, in agreement with previous results [19, 20].
No one particular class of drugs or mechanism of action is specifically associated with DILI, and many liver diseases are known to cause increased liver function levels (eg, viral hepatitis, acute cholestasis, biliary tract disorders, and liver cirrhosis), making DILI challenging to detect (Figure 1).
A liver profile test panel showed mild increases in transaminases, increased alkaline phosphatase activity, hypoalbuminemia, significant hyperbilirubinemia, and evidence of cholestasis with increased bile acids in the blood.
Bland cholestasis is probably due to toxicity at the level of the canaliculus, probably involving transporter molecules.
In some predisposed women, the metabolic changes are adequately severe to lead to development of gestational disorders of pregnancy including gestational diabetes mellitus (GDM) and intrahepatic cholestasis of pregnancy (ICP).
In December 2012, three premature infants with cholestasis hospitalized in Washington, DC, experienced erosive dermatitis in the diaper area and blisters on their extremities, a condition that can be associated with zinc deficiency (1).
After poisoning in animal with this toxicant lentadenes causes cholestasis which undergoes photochemical reactions on exposure to sunlight, which causes photosensitization and associated skin lesions.
It demonstrated marked cholestasis and a paucity of bile ducts (Figs 1 and 2).
ClickPress, Thu May 09 2013] GlobalData's clinical trial report, "Cholestasis Global Clinical Trials Review, H1, 2013" provides data on the Cholestasis clinical trial scenario.
PNALD is an umbrella term that encompasses several conditions, including cholestasis, which results from a buildup of excess bile acids in the liver, and steatosis, which--as its "fatty liver" nickname implies--occurs when there is too much fat in the liver.
The results suggest for the first time that the use of miroestrol and deoxymiroestrol-containing products as alternative medicines or health supplements should be concerned according to their effects on key genes that regulate the bile salt export pump, which could result in the risk of hepatotoxicity and intrahepatic cholestasis.
Alagille syndrome, and progressive familial intrahepatic cholestasis (PFIC) syndromes