Farrukh Saeed discussed treatment options for adult Cholestatic
Idiosyncratic DILI is more common than intrinsic DILI and can be classified into hepatocellular injury, cholestatic
injury, mixed hepatocellular-cholestatic
injury, and vascular injury.
The ascending pathophysiology of cholestatic
Familial intrahepatic cholestasis (FIC) comprises a group of rare cholestatic
liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4.
The gradual increase in the number of recent studies suggests that prevention of oxidative stress can play a significant role in preventing cholestatic
EASL Clinical Practice Guidelines: management of cholestatic
5 Specific histological features can help differentiate hepatitis, cholestatic
liver disease, steatosis, vascular abnormalities, infectious diseases, and infiltrative or storage diseases.
Splanchnic Th (2) and Th (1) cytokine redistribution in microsurgical cholestatic
have reported tacrolimus induced cholestatic
syndrome following pediatric liver transplantation.
Primary Biliary Cirrhosis (PBC) is an idiopathic, cholestatic
destruction of intra-hepatic microscopic bile ducts.
Set 1: clinical or biochemical hepatic abnormalities for at least 6 months; clinical or histological stigmata of liver disease; a sibling affected by progressive familial intrahepatic cholestasis or benign recurrent intrahepatic cholestasis; recurrent and episodic cholestatic
disease (without identifiable cause) occurring on more than 2 occasions, the episodes of which are separated by at least 3 months.
Data from a Phase 1 study demonstrated the biological activity and safety profile of GS-9674 in healthy volunteers and support the evaluation of this compound in patients with NASH and cholestatic