There is a significant unmet medical need for new treatments for cholestatic
liver diseases," stated Marlyn Mayo, M.
Disorders due to defects in this process (Inherited Cholestatic
Disorders, ICDs) lead to progressive liver disease.
The R&D Leadership Team will highlight a number of programs in Shire's research portfolio, as well as provide updates on several clinical programs in development, including SHP606 (lifitegrast) in Dry Eye Disease, SHP625 (LUM001) in Cholestatic
Liver Disease, SHP626 (LUM002) for adults with Nonalcoholic Steatohepatitis (NASH), and SHP607 for the prevention of Retinopathy of Prematurity (ROP).
The alliance facilitates the availability of the B-CLEAR[R] technology, which can be used to predict the biliary excretion of drugs, evaluate clinically relevant drug interactions, determine the cholestatic
potential of drugs, and estimate their intracellular concentration.
They present an algorithmic approach to thinking about common liver diseases and discuss the evaluation and management of early liver disease, special considerations for patients with advanced liver disease/cirrhosis, hepatocellular carcinoma and cholangiocarcinoma, the evaluation of transplant candidates, long-term management of the liver transplant recipient, hepatitis B and C, alcoholic and nonalcoholic fatty liver disease, autoimmune and cholestatic
diseases, and inherited metabolic liver diseases.
This was compatible with the suspected diagnosis of flucloxacillin drug-induced cholestatic
liver injury, but also raised concern about the so-called 'vanishing bile duct syndrome' (VBDS).
Co-trimoxazole can cause a cholestatic
picture alone or a hepatocellular and cholestatic
Ursodeoxycholic acid (UDCA) has been used in adult cholestatic
diseases, such as primary biliary cirrhosis and primary sclerosing cholangitis, with evidence of benefit.
It has been suggested that AT may trigger autoimmune hepatitis, with cases of AT induced acute hepatitis, acute cholestatic
hepatitis after AT treatment and a case of liver failure being reported.
Symptoms like hepatic dysfunction including increased enzyme levels, hepatocellular or cholestatic
hepatitis and fulminant failure have been reported with clarithromycin, erythromycin, and telithromycin (Scheinfeld, 2004, Mehta, 2008, Nogid 2005, Zimmerman et al.
A 33 weeks' gestation, a baby with rhesus hemolytic disease (RHD), who had received intrauterine transfusions twice, developed cholestatic
hepatic disease and late hyporegenerative anemia.
The goal of this study was to evaluate the effect of green tea cathechin therapy in hepatic tissue injury using cholestatic
rats with bile duct ligation.