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choriocarcinoma

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.02 sec.
cho·ri·o·car·ci·no·ma  (kôr--kärs-nm, kr-)
n. pl. cho·ri·o·car·ci·no·mas or cho·ri·o·car·ci·no·ma·ta (-m-t)
A malignant tumor that develops from trophoblast cells and usually occurs in the uterus.

choriocarcinoma
a uterine malignancy that may develop shortly after conception, during pregnancy, or after an abortion. Also called chorioblastoma, chorionic epithelioma.
See also: Cancer


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Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells.
Moreover, none of the genes reported to be up- or down-regulated in response to BaP in other systems [p53 in A549 or 3T3 cells (24), c-myc and transforming growth factor (TGF)-[Beta] in a placental choriocarcinoma cell line (25), and glutathione-S-transferase (GST)-Ya in HEPG2 cells (26)] responded to BaP at any of the doses or times studied.
There was a large increase in adverse reproductive outcomes, including stillbirths, spontaneous abortions, hydratidiform moles, and choriocarcinomas, after the period of application of Agent Orange.
 
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