In the latter case, splitting of one or both chromatid
sets according to our previously published concept (22) has to be considered.
Induction of sister chromatid
exchanges and chromosome aberrations in vivo in Etroplus suratensis (Bloch) following exposure to organophosphorus pesticides.
Examples of lethal aberrations to the cell are the dicentric and ring (which are chromosome aberrations) and the anaphase bridge (a chromatid
Sex chromosome loss, micronuclei, sister chromatid
exchange and aging: a study including 16 centenarians.
This sister chromatid
cohesion resists the pulling forces of the mitotic spindle and thereby enables the bi-orientation and subsequent symmetrical segregation of chromosomes.
The other mechanism, homologous repair, involves an undamaged DNA molecule that will be used as a template (the DNA of the sister chromatid
or the other chromosome).
Short term tests include acute toxicity, sister chromatid
analysis, gross chromosomal changes, formation of micronuclei and effects on DNA.
asiatica induced by cyproterone acetate (CPA) on human lymphocytes using chromosomal aberrations and sister chromatid
exchanges as parameters.
12] who looked at chromatid
breaks in young breast cancer patients and noted significantly higher chromatid
breaks in white American breast cancer patients than white controls, but not in African-American breast cancer patients compared with black controls.
Scientists from Japan, Europe, and the US discuss the history of mitosis research and the model systems that have played a key role; how threads are produced through chromosome condensation; how sister chromatids
attach to each other and to the spindle apparatus; how the spindle microtubules nucleate, elongate, pause, and shrink; how kinetochores and centrosomes serve as anchor and control points; the biochemical elements that coordinate the main regulatory stages of entry into mitosis, sister chromatid
separation, and mitotic exit; how cells can mis-segregate and unbalance the genome; the cellular changes that occur during cytokinesis; and the differences between mitosis and meiosis.
It happens during DNA replication and uses sister chromatid
as a template to repair the DNA double-strand break (21).
segregation, called random chromatid
segregation and maximum equational