Although chromosomal aberration
studies are very common in human genetic analysis and cancer research, micronuclei are the cytogenetic end point most often used for current human exposure biomonitoring studies.
Spontaneous level of chromosomal aberrations
in peripheral blood lymphocytes of control individuals of the Czech Republic population.
In vitro chromosomal aberration
test was performed on treated as well as untreated bone marrow mesenchymal cells.
A total of 5000 cells per concentration were examined for dividing cells and chromosomal aberrations
using oil immersion objective lens.
Phytosterols showed protective effect, whereas clerodane diterpenoid was less effective to MMS induced chromosomal aberrations
2) derivative chromosomes, supports the view that identical cytogenetic changes in multiple leiomyomas from the same patient may represent recurrent chromosomal aberrations
in smooth muscles or they may be coincidental.
Cytogenetic biomarkers, notably structural chromosomal aberrations
(7) and micronuclei (8), have been shown to predict cancer risk at group level, and offer the premise to act as valid tools in cancer surveillance and prevention programmes in occupational and environmental health.
1997, "Allium cepa anaphase-telophase root tip chromosomal aberration
assay on N-methyl-N-nitro urea, maleic hydrazide, sodium azide and ethylmetahne sulphonate," Mutat.
Root tips of Vicia feba for the study of induction of chromosomal aberrations
A standard battery of genetic toxicology studies (the Ames Assay performed in bacteria, the Mouse Micronucleus Test, and the Chromosomal Aberration
Assay, using human peripheral blood lymphocytes) were performed under rigorous standards referred to as current Good Laboratory Practices (cGLPs).
In a third of clinical cases, UPD is actually uncovered through a chromosomal aberration
frequency ranging 50-80 per cent have been reported in studies using F1SH and conventional cytogenetics (22,22) The two reported studies from India showed 37.