chromosomal aberration


Also found in: Thesaurus, Medical, Legal, Acronyms, Encyclopedia, Wikipedia.
Related to chromosomal aberration: aneuploidy, gene mutation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.chromosomal aberration - any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities
aberrance, aberrancy, aberration, deviance - a state or condition markedly different from the norm
monosomy - chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number
trisomy - chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell
sex-linked disorder - any disease or abnormality that is determined by the sex hormones; "hemophilia is determined by a gene defect on an X chromosome"
References in periodicals archive ?
Although chromosomal aberration studies are very common in human genetic analysis and cancer research, micronuclei are the cytogenetic end point most often used for current human exposure biomonitoring studies.
Spontaneous level of chromosomal aberrations in peripheral blood lymphocytes of control individuals of the Czech Republic population.
In vitro chromosomal aberration test was performed on treated as well as untreated bone marrow mesenchymal cells.
A total of 5000 cells per concentration were examined for dividing cells and chromosomal aberrations using oil immersion objective lens.
Phytosterols showed protective effect, whereas clerodane diterpenoid was less effective to MMS induced chromosomal aberrations.
2) derivative chromosomes, supports the view that identical cytogenetic changes in multiple leiomyomas from the same patient may represent recurrent chromosomal aberrations in smooth muscles or they may be coincidental.
Cytogenetic biomarkers, notably structural chromosomal aberrations (7) and micronuclei (8), have been shown to predict cancer risk at group level, and offer the premise to act as valid tools in cancer surveillance and prevention programmes in occupational and environmental health.
1997, "Allium cepa anaphase-telophase root tip chromosomal aberration assay on N-methyl-N-nitro urea, maleic hydrazide, sodium azide and ethylmetahne sulphonate," Mutat.
Root tips of Vicia feba for the study of induction of chromosomal aberrations.
A standard battery of genetic toxicology studies (the Ames Assay performed in bacteria, the Mouse Micronucleus Test, and the Chromosomal Aberration Assay, using human peripheral blood lymphocytes) were performed under rigorous standards referred to as current Good Laboratory Practices (cGLPs).
In a third of clinical cases, UPD is actually uncovered through a chromosomal aberration.
Chromosomal aberration frequency ranging 50-80 per cent have been reported in studies using F1SH and conventional cytogenetics (22,22) The two reported studies from India showed 37.